42861-71-2

Basic information

• Product Name: 3-IODOPHENYL ACETATE
• Synonyms: Acetic acid 3-iodo-phenyl ester
• CAS NO: 42861-71-2
• Molecular Formula: C₈H₇IO₂
• Molecular Weight: 262.04
• Mol File: 42861-71-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-IODOPHENYL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODOPHENYL ACETATE(42861-71-2)
• EPA Substance Registry System: 3-IODOPHENYL ACETATE(42861-71-2)

Safety Data

• Hazardous Substances Data: 42861-71-2(Hazardous Substances Data)

Upstream product

• 18001-12-2 m-(Trimethylsilyl)phenyl Acetate 
• 626-02-8 3-Iodophenol 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 17881-95-7 m-(Trimethylsilyl)phenol 
• 591-50-4 iodobenzene 
• 3240-34-4 [bis(acetoxy)iodo]benzene 

Downstream Products

• 626-02-8 3-Iodophenol 
• 89942-32-5 1-(4-hydroxy-2-iodo-phenyl)-ethanone 
• 39730-66-0 1-(2-hydroxy-4-iodophenyl)ethan-1-one 
• 18450-38-9 1,3-Bis-(3-acetoxy-phenyl)-perfluor-propan 
• 25444-22-8 1-(3-Acetoxy-phenyl)-3H-perfluor-propan 
• 21250-10-2 3-Acetoxy-1-(perfluor-propyl)-benzol 
• 122-46-3 3-acetoxytoluene 
• 474658-40-7 3-[1,1-bis(methylethyl)-2-methyl-1-silapropylthio]phenyl acetate 
• 474658-41-8 ethyl 5-(3-acetyloxyphenylthio)-4-oxopentanoate 
• 649551-69-9 2'-hydroxy-4'-iodo-3,4,5-trimethoxy-chalcone 
• 649551-71-3 3-benzyloxy-7-iodo-2-(3,4,5-trimethoxyphenyl)-chromen-4-one 
• 649551-77-9 3-hydroxy-7-iodo-2-(4-benzyloxy-3,5-dimethoxyphenyl)-chromen-4-one 
• 649551-78-0 3-benzyloxy-7-iodo-2-(4-benzyloxy-3,5-dimethoxy-phenyl)-chromen-4-one 
• 649551-82-6 3-benzyloxy-2-(4-benzyloxy-3,5-dimethoxy-phenyl)-7-(3,7-dimethyl-octyl)-chromen-4-one 

Relevant articles and documents

Steric effect of NHC ligands in Pd(II)–NHC-catalyzed non-directed C–H acetoxylation of simple arenes

Although there has been a lot of progress in oxidative arene C–H functionalization reactions catalyzed by Pd(II/IV) system, the non-directed, site-selective functionalization of arene molecules is still challenging. It has been established that ligands play a pivotal role in controlling rate- as well as selectivity-determining step in a catalytic cycle involving well-defined metal-ligand bonding. N-heterocyclic carbene (NHC) ligands have had a tremendous contribution in the recent extraordinary success of achieving high reactivity and excellent selectivity in many catalytic processes including cross-coupling and olefin-metathesis reactions. However, the immense potential of these NHC ligands in improving site-selectivity of non-directed catalytic C–H functionalization reactions of simple arenes is yet to be realized, where overriding the electronic bias on deciding selectivity is a burdensome task. The presented work demonstrated an initiative step in this regard. Herein, a series of well-defined discrete [Pd(NHCR′R)(py)I2] complexes with systematically varied degree of spatial congestion at the Pd centre, exerted through the R and R’ substituents on the NHC ligand, were explored in controlling the activity as well as the site-selectivity of non-directed acetoxylation of representative monosubstituted and disubstituted simple arenes (such as toluene, iodobenzene and bromobenzene, naphthalene and 1,2-dichlorobenzene). The resulting best yields were found to be 75% for toluene and 65% for bromobenzene with [Pd(NHCMePh)(py)I2], 75% for iodobenzene and 79% for naphthalene with [Pd(NHCMeMe)(py)I2], and 41% for 1,2-dichlorobenzene with [Pd(NHCCyCy)(py)I2]. Most importantly, with increasing the bulkiness of the NHC ligand in the complexes, the selectivity of the distal C-acetoxylated products in comparison to the proximal ones, was enhanced to a great extent in all cases. Considering the vast library of NHC ligands, this study underscores the future opportunity to develop more strategies to improve the activity and the crucial site-selectivity of C–H functionalization reactions in simple as well as complex organic molecules.

Dibenzofuran derivatives inspired from cercosporamide as dual inhibitors of pim and CLK1 kinases

Pim kinases (proviral integration site for Moloney murine leukemia virus kinases) are overexpressed in various types of hematological malignancies and solid carcinomas, and promote cell proliferation and survival. Thus, Pim kinases are validated as targets for antitumor therapy. In this context, our combined efforts in natural product-inspired library generation and screening furnished very promising dibenzo[b, d]furan derivatives derived from cercosporamide. Among them, lead compound 44 was highlighted as a potent Pim-1/2 kinases inhibitor with an additional nanomolar IC50 value against CLK1 (cdc2-like kinases 1) and displayed a low micromolar anticancer potency towards the MV4-11 (AML) cell line, expressing high endogenous levels of Pim-1/2 kinases. The design, synthesis, structure-activity relationship, and docking studies are reported herein and supported by enzyme, cellular assays, and Galleria mellonella larvae testing for acute toxicity.

Aryl ethynyl anthraquinones: A useful platform for targeting telomeric G-quadruplex structures

Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properti