42867-34-5

Basic information

• Product Name: 1-((4-METHYLPHENYL)METHYL)-1H-PYRROLE-2,5-DIONE
• Synonyms: N-((4-METHYLPHENYL)METHYL)MALEIMIDE;AKOS MSC-0040;1-((4-METHYLPHENYL)METHYL)-1H-PYRROLE-2,5-DIONE;Nsc186043;1-[(4-methylphenyl)methyl]pyrrole-2,5-dione
• CAS NO: 42867-34-5
• Molecular Formula: C₁₂H₁₁NO₂
• Molecular Weight: 201.22
• Mol File: 42867-34-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 353.3 °C at 760 mmHg
• Flash Point: 162 °C
• Appearance: /
• Density: 1.252 g/cm³
• Vapor Pressure: 3.63E-05mmHg at 25°C
• Refractive Index: 1.612
• PKA: -2.32±0.20(Predicted)
• CAS DataBase Reference: 1-((4-METHYLPHENYL)METHYL)-1H-PYRROLE-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((4-METHYLPHENYL)METHYL)-1H-PYRROLE-2,5-DIONE(42867-34-5)
• EPA Substance Registry System: 1-((4-METHYLPHENYL)METHYL)-1H-PYRROLE-2,5-DIONE(42867-34-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 42867-34-5(Hazardous Substances Data)

Usage

General Description

The chemical compound 1-((4-methylphenyl)methyl)-1H-pyrrole-2,5-dione, also known as 4'-Methylpropiophenone or 4'-Methylpropiophenone, is a pyrrole-2,5-dione derivative with a 4-methylphenylmethyl substituent. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds due to its versatile reactivity and functional groups. This chemical has potential applications in medicinal chemistry and drug discovery as a building block for the development of novel pharmaceutical agents. Additionally, it may also be used in organic synthesis and as a reagent in chemical reactions to introduce its specific functionalities into target molecules.

InChI:InChI=1/C12H11NO2/c1-9-2-4-10(5-3-9)8-13-11(14)6-7-12(13)15/h2-7H,8H2,1H3

Upstream product

• 64198-96-5 (Z)-3-(4-methylbenzylcarbamoyl)acrylic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 108-31-6 maleic anhydride 
• 104-84-7 para-methylbenzylamine 
• 3235-02-7 p-methylbenzaldehyde oxime 
• 64-17-5 ethanol 
• 94054-40-7 1-(4-methylbenzyl)-1H-pyrrole 

Downstream Products

• 1416803-69-4 4-(N-(4-methylbenzyl)pyrrolidin-3-yl-2,5-dione)-7-oxa-2-azabicyclo[2.2.1]hept-5-ene 

Relevant articles and documents

Visible light dye-photosensitised oxidation of pyrroles using a simple LED photoreactor

The photooxidation of pyrrole is typically low yielding due to the absorbance of ultraviolet light, which leads to uncontrolled polymerisation and decomposition. Presented herein is the development of a simple and cost-effective photoreactor utilising Light Emitting Diodes (LEDs) as the light source, and its application to the dye-sensitised oxidation of a range of pyrroles to give corresponding 3-pyrrolin-2-ones. The broader applicability of this approach to the generation of 1O2 is also explored.

An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model

An unexpected intramolecular cyclization during the reaction of furfurylamine with maleimides is reported as a novel strategy for the efficient green synthesis of the 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton. Under the same reaction conditions, 7-oxabicyclo[2.2.1]hept-5-enes were synthesized when furfurylamine was N-protected by the acetyl group. Both types of bicycloheptenes were screened using the zebrafish model system for genetics and developmental biology. The Royal Society of Chemistry 2013.