42870-65-5

Basic information

• Product Name: N-CYCLOHEPTYL-N-METHYLAMINE
• Synonyms: N-methylcycloheptanamine(SALTDATA: HCl);N-MethylcycloheptanaMine;N-Cycloheptylmethylamine
• CAS NO: 42870-65-5
• Molecular Formula: C₈H₁₇N
• Molecular Weight: 127.2273
• Mol File: 42870-65-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 168.7°Cat760mmHg
• Flash Point: 43.4°C
• Appearance: /Solid
• Density: 0.84g/cm³
• Vapor Pressure: 1.6mmHg at 25°C
• Refractive Index: 1.452
• PKA: 11.03±0.20(Predicted)
• CAS DataBase Reference: N-CYCLOHEPTYL-N-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CYCLOHEPTYL-N-METHYLAMINE(42870-65-5)
• EPA Substance Registry System: N-CYCLOHEPTYL-N-METHYLAMINE(42870-65-5)

Safety Data

• Hazardous Substances Data: 42870-65-5(Hazardous Substances Data)

Usage

Description

N-CYCLOHEPTYL-N-METHYLAMINE, also known as cycloheptylmethylamine, is a chemical compound with the molecular formula C8H17N. It is a primary amine featuring a seven-membered cycloheptyl ring and a methyl group attached to the nitrogen atom. This colorless liquid with a strong odor is sensitive to air and light, and requires careful handling due to its potential to cause respiratory irritation and skin corrosion. Moreover, it is flammable and may form explosive peroxides upon exposure to air.

Uses

Used in Pharmaceutical Industry:
N-CYCLOHEPTYL-N-METHYLAMINE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of various medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, N-CYCLOHEPTYL-N-METHYLAMINE serves as an intermediate, playing a crucial role in the production of agrochemicals that are vital for agricultural applications.
Used as a Precursor in Organic Compounds Production:
N-CYCLOHEPTYL-N-METHYLAMINE is also utilized as a precursor for the production of other organic compounds, highlighting its versatility in the field of organic chemistry.

InChI:InChI=1/C8H17N/c1-9-8-6-4-2-3-5-7-8/h8-9H,2-7H2,1H3

Upstream product

• 74-89-5 methylamine 
• 502-42-1 cycloheptanone 
• 593-51-1 methylamine hydrochloride 
• 56553-60-7 sodium tris(acetoxy)borohydride 

Downstream Products

• 529-17-9 tropane 
• 105695-12-3 N-Cycloheptyl-4-(3-formyl-4-nitro-phenoxy)-N-methyl-butyramide 
• 67227-02-5 N-Methyl-N-cycloheptyl-N'-guanyl-aethylendiamin 
• 229004-48-2 N-(4-((N-cycloheptyl-N-methyl)aminomethyl)phenyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide 
• 1186211-97-1 4-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-methylbenzamide 

Relevant articles and documents

Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae

Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C4–C8) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94–96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.

Anilide derivative, production and use thereof

This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring: C is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof, which is useful for antagonizing MCP-1 receptor.