42872-86-6Relevant articles and documents
Phosphine-catalyzed remote β-C-H functionalization of amines triggered by trifluoromethylation of alkenes: One-pot synthesis of bistrifluoromethylated enamides and oxazoles
Yu, Peng,Zheng, Sheng-Cai,Yang, Ning-Yuan,Tan, Bin,Liu, Xin-Yuan
supporting information, p. 4041 - 4045 (2015/03/30)
An unprecedented phosphine-catalyzed remote β-C-H functionalization of amine derivatives triggered by trifluoromethylation of an alkene with Togni's reagent was disclosed. This reaction proceeded through the highly selective and concomitant activation of
Palladium-catalyzed highly selective ortho-halogenation (I, Br, Cl) of arylnitriles via sp2 C-H bond activation using cyano as directing group
Du, Bingnan,Jiang, Xiaoqing,Sun, Peipei
, p. 2786 - 2791 (2013/04/24)
A palladium-catalyzed ortho-halogenation (I, Br, Cl) of arylnitrile is described. The optimal reaction conditions were identified after examining various factors such as catalyst, additive, solvent, and reaction temperature. Using cyano as the directing group, the halogenation reaction gave good to excellent yields. The method is compatible to the arylnitriles with either electron-withdrawing or electron-donating groups. The reaction is available to the substrate in at least gram scale. The present method was successfully applied to the synthesis of the precursors of paucifloral F and isopaucifloral F.
