42920-79-6Relevant articles and documents
Synthesis of N-succinyl-L, L-diaminopimelic Acid mimetics via selective protection
Vanek,Picha,Budesinsk,Sanda,Jiracek,Holz,Hlavacek
scheme or table, p. 405 - 409 (2011/11/05)
The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) has stimulated a development of methodology for quick and efficient preparation of mono-N-acylated 2,6-diaminop
Synthesis of RP 56142: a New Immunoactive Peptide
Bouchaudon, Jean,Dutruc-Rosset, Gilles,Farge, Daniel,James, Claude
, p. 695 - 701 (2007/10/02)
RP 56142, a new immunoactive peptide was synthesized on large scale (ca. 500 g) via L-2,6-diaminopimelic acid which was prepared by chemical or biochemical synthesis.The key derivative, N6-benzyloxycarbonyl-L-2,6-diaminopimelamic acid was synthesized by two methods.In the first, we used a copper chelate procedure.In the second, we selectively deblocked the amine at the α-position to the free carboxylic group by the N-carboxyanhydride method.Condensation of N6-benzyloxycarbonyl-L-2,6-diaminopimelamic acid and the appropriately protected lauroyl dipeptide and removal of the protecting groups afforded RP 56142.
Synthesis of the tripeptides of meso-alpha,alpha'-diaminopimelic acid and of L- and D-alanine.
BRICAS,NICOT,VAN HEIJENOORT
, p. 1685 - 1687 (2007/10/05)
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