42945-18-6

Basic information

• Product Name: 2-[1-(hydroxymethyl)propyl]-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-[1-(hydroxymethyl)propyl]-1H-isoindole-1,3(2H)-dione
• CAS NO: 42945-18-6
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.23652
• Mol File: 42945-18-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[1-(hydroxymethyl)propyl]-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(hydroxymethyl)propyl]-1H-isoindole-1,3(2H)-dione(42945-18-6)
• EPA Substance Registry System: 2-[1-(hydroxymethyl)propyl]-1H-isoindole-1,3(2H)-dione(42945-18-6)

Safety Data

• Hazardous Substances Data: 42945-18-6(Hazardous Substances Data)

Upstream product

• 96-20-8 2-aminobutanol 
• 85-44-9 phthalic anhydride 

Downstream Products

• 66072-87-5 N-[1-(toluene-4-sulfonyloxymethyl)-propyl]-phthalimide 
• 98289-81-7 (3S,9bR)-3-Ethyl-2,3-dihydro-9bH-oxazolo[2,3-a]isoindol-5-one 
• 98289-81-7 3-ethyl-2,3-dihydro-<1,3>oxazolo<2,3-a>isoindol-5(9bH)-one 
• 10108-61-9 N-(1-methylpropyl)phthalimide 
• 42945-17-5 1-benzyl-3-[(2-ethyl-2-phthalimido)ethoxy]-1H-indazole 
• 42945-19-7 N-(1-bromomethyl-propyl)-phthalimide 
• 1666-13-3 diphenyl diselenide 
• 1312023-08-7 2-{1-[(methoxymethoxy)methyl]propyl}-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

Acid-mediated intramolecular cationic cyclization using an oxygen atom as internal nucleophile: Synthesis of substituted oxazolo-, oxazino- and oxazepinoisoindolinones

Efficient assembly of substituted oxazolo-, oxazino-, and oxazepinoisoindolinones (5-7, 12-15 and 19) is described in three steps according to an acidic α-oxoamidoalkylation reaction from ready available phthalic anhydride by successive imidation, sodium borohydride reduction and intramolecular cationic cyclization involving N-acyliminium species. The relative stereochemistry accompanying these reactions was also discussed.

Synthesis of (R)- and (S)-2-Aminobutane from (S)- and (R)-2-Aminobutanol

(R)-(-)- and (S)-(+)-2-Aminobutane (1) can be synthesized in good yield and high optical purity from (S)-(+)- and (R)-(-)-2-aminobutanol (2) respectively.