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4298-05-9

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4298-05-9 Usage

Description

CIS-3-HYDROXY-DL-PROLINE is a derivative of DL-Proline, which is a racemic mixture of both L-Proline and D-Proline. It is an amino acid that plays a significant role in various biological processes and has potential applications in different industries due to its unique properties.

Uses

Used in Pharmaceutical Industry:
CIS-3-HYDROXY-DL-PROLINE is used as an active pharmaceutical ingredient for its potential therapeutic effects. It is involved in the synthesis of collagen and other proteins, making it essential for maintaining the structural integrity of tissues and organs.
Used in Cosmetic Industry:
CIS-3-HYDROXY-DL-PROLINE is used as a key ingredient in anti-aging and skin care products for its ability to promote collagen production and improve skin elasticity. It helps in reducing the appearance of fine lines and wrinkles, providing a more youthful and radiant complexion.
Used in Research and Development:
CIS-3-HYDROXY-DL-PROLINE is used as a research compound for studying its effects on various biological processes, such as cell proliferation, differentiation, and apoptosis. It can also be used in the development of new drugs and therapies targeting specific diseases and conditions.
Used in Food and Nutrition Industry:
CIS-3-HYDROXY-DL-PROLINE is used as a nutritional supplement to support collagen synthesis and overall health. It can be added to various food products and dietary supplements to enhance their nutritional value and promote better health and well-being.
Used in Agricultural Industry:
CIS-3-HYDROXY-DL-PROLINE can be used in the development of plant growth regulators and stress resistance enhancers. It may help improve crop yield and quality by promoting cell growth and protecting plants from various environmental stresses.

Check Digit Verification of cas no

The CAS Registry Mumber 4298-05-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,9 and 8 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4298-05:
(6*4)+(5*2)+(4*9)+(3*8)+(2*0)+(1*5)=99
99 % 10 = 9
So 4298-05-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H9NO3/c7-3-1-2-6-4(3)5(8)9/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1

4298-05-9 Well-known Company Product Price

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  • Aldrich

  • (420174)  cis-3-Hydroxy-DL-proline  95%

  • 4298-05-9

  • 420174-10MG

  • 4,523.22CNY

  • Detail

4298-05-9Relevant articles and documents

Modular Chemoenzymatic Synthesis of GE81112 B1 and Related Analogues Enables Elucidation of Its Key Pharmacophores

Zwick, Christian R.,Sosa, Max B.,Renata, Hans

supporting information, p. 1673 - 1679 (2021/01/25)

The GE81112 complex has garnered much interest due to its broad antimicrobial properties and unique ability to inhibit bacterial translation initiation. Herein we report the use of a chemoenzymatic strategy to complete the first total synthesis of GE81112 B1. By pairing iron and α-ketoglutarate dependent hydroxylases found in GE81112 biosynthesis with traditional synthetic methodology, we were able to access the natural product in 11 steps (longest linear sequence). Following this strategy, 10 GE81112 B1 analogues were synthesized, allowing for identification of its key pharmacophores. A key feature of our medicinal chemistry effort is the incorporation of additional biocatalytic hydroxylations in modular analogue synthesis to rapidly enable exploration of relevant chemical space.

Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles

Smart, Tristan J.,Hamed, Refaat B.,Claridge, Timothy D.W.,Schofield, Christopher J.

supporting information, (2019/11/26)

Studies on the substrate selectivity of recombinant ferrous-iron- and 2-oxoglutarate-dependent proline hydroxylases (PHs) reveal that they can catalyse the production of dihydroxylated 5-, 6-, and 7-membered ring products, and can accept bicyclic substrates. Ring-substituted substrate analogues (such hydroxylated and fluorinated prolines) are accepted in some cases. The results highlight the considerable, as yet largely untapped, potential for amino acid hydroxylases and other 2OG oxygenases in biocatalysis.

Regio- and stereoselective oxygenation of proline derivatives by using microbial 2-oxoglutarate-dependent dioxygenases

Hara, Ryotaro,Uchiumi, Naoko,Okamoto, Naoko,Kino, Kuniki

, p. 1384 - 1388 (2015/07/20)

We evaluated the substrate specificities of four proline cis-selective hydroxylases toward the efficient synthesis of proline derivatives. In an initial evaluation, 15 proline-related compounds were investigated as substrates. In addition to L-proline and L-pipecolinic acid, we found that 3,4-dehydro-L-proline, L-azetidine-2-carboxylic acid, cis-3-hydroxy-L-proline, and L-thioproline were also oxygenated. Subsequently, the product structures were determined, revealing cis-3,4-epoxy-L-proline, cis-3-hydroxy-L-azetidine-2-carboxylic acid, and 2,3-cis-3,4-cis-3,4-dihydroxy-L-proline.

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