430470-54-5

Basic information

• Product Name: N-(2-methoxyphenyl)-N'-(pyridin-2-yl)oxalamide
• Synonyms: N-(2-methoxyphenyl)-N'-(pyridin-2-yl)oxalamide
• CAS NO: 430470-54-5
• Molecular Weight: 271.276
• Mol File: 430470-54-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-methoxyphenyl)-N'-(pyridin-2-yl)oxalamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methoxyphenyl)-N'-(pyridin-2-yl)oxalamide(430470-54-5)
• EPA Substance Registry System: N-(2-methoxyphenyl)-N'-(pyridin-2-yl)oxalamide(430470-54-5)

Safety Data

• Hazardous Substances Data: 430470-54-5(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 62134-49-0 N-(2-pyridyl)-3-carboxypropionamide 
• 90-04-0 2-methoxy-phenylamine 
• 504-29-0 2-aminopyridine 
• 76475-60-0 N-[(2-methoxyphenyl)]-4-oxo-4-[oxy]butanamide 

Relevant articles and documents

Ligand-based modelling followed by synthetic exploration unveil novel glycogen phosphorylase inhibitory leads

Glycogen phosphorylase (GP) is a valid anti-diabetic target. Accordingly, we applied a drug discovery workflow to unveil novel inhibitory GP leads via combining pharmacophore modeling, QSAR analysis and in silico screening, followed by synthetic exploration of active hits. Virtual screening identified six low micromolar inhibitory leads from the National Cancer Institute (NCI) list of compounds. The most potent hits exhibited anti-GP IC50 values of 3.2 and 4.1 μM. Synthetic exploration of hit 59 (IC50 = 4.1 μM) yielded 25 lead inhibitors with the best illustrating IC50 of 3.0 μM. Interestingly, we prepared several novel mixed oxalyl amide anti-GP leads employing new chemical reaction involving succinic acid-based adducts.