43058-57-7

Basic information

• Product Name: Benzeneacetonitrile, a-hydroxy-a-propyl-
• Synonyms: Butyrophenon-cyanhydrin;Butyrophenoncyanhydrin;α-Oxy-α-phenyl-n-valeronitril;2-Hydroxy-2-phenyl-valeronitril
• CAS NO: 43058-57-7
• Molecular Formula: C11H13NO
• Molecular Weight: 175.22700
• Mol File: 43058-57-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, a-hydroxy-a-propyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, a-hydroxy-a-propyl-(43058-57-7)
• EPA Substance Registry System: Benzeneacetonitrile, a-hydroxy-a-propyl-(43058-57-7)

Safety Data

• Hazardous Substances Data: 43058-57-7(Hazardous Substances Data)

Upstream product

• 140-29-4 phenylacetonitrile 
• 5558-78-1 2-phenyl-pentanenitrile 

Downstream Products

• 2019-67-2 2-hydroxy-2-phenyl-valeric acid amide 
• 4445-16-3 2-hydroxy-2-phenyl-valeric acid 
• 130689-85-9 5-phenyl-5-propyl-oxazolidine-2,4-dione 
• 5394-37-6 NSC 1023 

Relevant articles and documents

Oxidative Decyanation of Secondary Nitriles to Ketones

Procedures for the oxidative decyanation of secondary nitriles to ketones involve (1) iodination of N-(trialkylsilyl)ketenimines derived from secondary nitriles and subsequent hydrolysis of the α-iodo nitriles with silver oxide, (2) addition of nitrosobenzene to N-(trialkylsilyl)ketenimines, (3) conversion of secondary nitriles to α-(phenylthio) nitriles and subsequent hydrolysis with N-bromosuccinimide in aqueous acetonitrile, and (4) preparation of α-hydroperoxy nitriles by direct oxygenation of anions of secondary nitriles and subsequent reductive hydrolysis with stannous chloride followed by sodium hydroxide.The latter general procedure was applied to various secondary nitriles bearing dialkyl, aryl and alkyl, and diaryl substituents to provide ketones in good yield and was extended to the oxidative decyanation of α,β-unsaturated nitriles to furnish α,β-unsaturated ketones.