43071-31-4

Basic information

• Product Name: 4-carboxy-2-phenyl-3-quinolineacetic acid
• Synonyms: 4-carboxy-2-phenyl-3-quinolineacetic acid
• CAS NO: 43071-31-4
• Molecular Weight: 307.306
• Mol File: 43071-31-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-carboxy-2-phenyl-3-quinolineacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-carboxy-2-phenyl-3-quinolineacetic acid(43071-31-4)
• EPA Substance Registry System: 4-carboxy-2-phenyl-3-quinolineacetic acid(43071-31-4)

Safety Data

• Hazardous Substances Data: 43071-31-4(Hazardous Substances Data)

Upstream product

• 91-56-5 indole-2,3-dione 
• 2051-95-8 succinylbenzene 

Downstream Products

• 43071-36-9 3-(carboxymethyl)-2-phenylquinoline-4-carboxylic acid anhydride 
• 402517-03-7 3-methyl-2-phenylquinoline-4-carbohydrazide 
• 5471-16-9 3-methyl-2-phenylquinoline-4-carboxylic acid ethyl ester 
• 43071-45-0 3-methyl-2-phenylquinoline-4-carboxylic acid 
• 887400-67-1 3-(methoxycarbonyl)methyl-2-phenyl-4-quinolinecarboxylic acid 

Relevant articles and documents

Preparation method for 3-linear alkylcarboxyl-substituted quinoline -4-carboxylic acid derivative

The invention discloses a preparation method for a 3-linear alkylcarboxyl-substituted quinoline -4-carboxylic acid derivative, which comprises the following steps: a certain concentration of aqueous alkali is added into a reaction bottle and uniformly sti

COMPOUNDS HAVING ACTIVITY AT NK3 RECEPTOR AND USES THEREOF IN MEDICINE

The invention also relates to compounds of formula (I), a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein R1 is phenyl or cyclohexyl, either of which is optionally substituted by 1, 2 or 3 halogen atoms, which atoms may be the same or different; R2 is C1-6alkyl or C3-6cycloalkyl; n is 1 or 2; R3 is hydrogen, C1-6alkyl or C3-6cycloalkyl; X is -(C=O)- or -SO2-; R4 is C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6haloalkoxy, amino, monoC1-6alkylamino or diC1-6alkylamino, or R4 is heterocyclyl or carbocyclyl, either of which is optionally substituted independently by one or more halogen, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy or C1-6haloalkoxy; R5 is phenyl or thienyl, either of which is optionally substituted by 1, 2 or 3 halogen atoms; and y is 0, 1 or 2; wherein when y is 1 or 2, Y is a halogen atom, and wherein when y is 2 the halogen atoms may be the same or different. Also disclosed are use of the compounds in treating diseases and conditions mediated by activation of the NK3 receptor, compositions containing the derivatives and processes for their preparation.