43107-11-5

Basic information

• Product Name: 2-Butenoic acid, 3-amino-, phenylmethyl ester
• CAS NO: 43107-11-5
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol File: 43107-11-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 3-amino-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 3-amino-, phenylmethyl ester(43107-11-5)
• EPA Substance Registry System: 2-Butenoic acid, 3-amino-, phenylmethyl ester(43107-11-5)

Safety Data

• Hazardous Substances Data: 43107-11-5(Hazardous Substances Data)

Upstream product

• 5396-89-4 benzyl acetoacetate 

Downstream Products

• 166809-88-7 3-(2-cyanoethoxycarbonyl)-5-(benzyloxycarbonyl)-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)pyridine 
• 915296-80-9 3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 915296-82-1 benzyl 4-(2,4-dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate 
• 915297-04-0 benzyl 6-(2-tert-butoxy-2-oxoethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate 
• 915296-81-0 3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methylpyridine-3,5-dicarboxylate 

Relevant articles and documents

Synthesis method of amlodipine besylate degradant impurities

The invention provides a preparation method of amlodipine besylate degradant impurities. The method comprises the following steps: a) preparation of a compound 1: generating corresponding imine, namely, the compound 1 by using an acetylacetic ester compou

Discovery and structure-activity relationships of pyrrolone antimalarials

In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced compound libraries was undertaken by the World Health Organisation Programme for Research and Training in Tropical Diseases (WHO-TDR). We report here the detailed characterization of one of the hits from this process, TDR32750 (8a), which showed potent activity against Plasmodium falciparum K1 (EC50 ～ 9 nM), good selectivity (>2000-fold) compared to a mammalian cell line (L6), and significant activity against a rodent model of malaria when administered intraperitoneally. Structure-activity relationship studies have indicated ways in which the molecule could be optimized. This compound represents an exciting start point for a drug discovery program for the development of a novel antimalarial.

Direct β-acyloxylation of enamines via PhIO-mediated intermolecular oxidative C-O bond formation and its application to the synthesis of oxazoles

A direct β-acyloxylation of enamine compounds has been achieved by using iodosobenzene (PhIO) as an oxidant to realize the intermolecular oxidative C(sp2)-O bond formation between enamines and various carboxylic acids, including N-protected amino acids. The transformation tolerates a wide range of functional groups and furnishes a variety of β-acyloxy enamines that can be conveniently converted to oxazole compounds via cyclodehydration.