432-98-4

Basic information

• Product Name: 2-Propanone, 1-[(4-fluorophenyl)sulfonyl]-
• CAS NO: 432-98-4
• Molecular Formula: C9H9FO3S
• Molecular Weight: 216.233
• Mol File: 432-98-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Propanone, 1-[(4-fluorophenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanone, 1-[(4-fluorophenyl)sulfonyl]-(432-98-4)
• EPA Substance Registry System: 2-Propanone, 1-[(4-fluorophenyl)sulfonyl]-(432-98-4)

Safety Data

• Hazardous Substances Data: 432-98-4(Hazardous Substances Data)

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 78-95-5 chloroacetone 
• 2968-13-0 1-(4-fluoro-phenylsulfanyl)propan-2-one 
• 371-42-6 4-Fluorothiophenol 
• 125704-76-9 1-Fluoro-4-(prop-1-yne-1-sulfonyl)-benzene 
• 111247-85-9 1-Fluoro-4-(prop-2-yne-1-sulfonyl)-benzene 
• 111247-77-9 1-Fluoro-4-(propa-1,2-diene-1-sulfonyl)-benzene 

Downstream Products

• 90357-06-5 Bicalutamide 
• 1083068-87-4 C₁₆H₂₃FN₂O₄S 
• 1083068-84-1 C₂₁H₂₄FNO₅S 
• 1083068-83-0 C₂₃H₂₆FNO₅S 
• 125704-81-6 N-[2-(4-Fluoro-benzenesulfonyl)-1-methyl-eth-(Z)-ylidene]-N'-phenyl-hydrazine 
• 125704-80-5 1-(4-fluorophenylsulfonyl)-2-propanone hydrazone 

Relevant articles and documents

Facile One-Pot Access to α-Diazo-β-ketosulfones from Sulfonyl Chlorides and α-Haloketones

A convenient one-pot approach to the preparation of α-diazo-β-ketosulfones from sulfonyl chlorides is described. It involves the conversion of the sulfonyl chloride to sodium sulfinate, alkylation of the latter with α-haloketones followed by diazo transfer using the 'sulfonyl-azide-free' ('SAFE') protocol in aqueous medium. The simple and expedient method relies on readily available starting materials and provides facile access to a wide variety of valuable diazo reagents for organic synthesis.

Multicomponent reactions as a powerful tool for generic drug synthesis

Multicomponent reactions (MCRs) are not only a powerful tool for drug discovery, they also represent an excellent methodology for synthesis rationalization. Here we wish to illustrate the potential of MCRs in the production of generic drugs by synthesizing, in racemic form, the antiplatelet agent clopidogrel and the nonsteroidal antiandrogen bicalutamide, using Ugi, Petasis and Passerini reactions. Georg Thieme Verlag Stuttgart.

HYDRATION OF 1- AND 3-ARYLSULFONYL-1-PROPYNES AND ARYLSULFONYLALLENES

The reactions of isomeric 1- and 3-arylsulfonyl-1-propynes and arylsulfonylallenes with primary aromatic amines in organic solvent-water system lead to arylsulfonyl-2-propanones.Unstable addition products (enamines) are formed in the reaction and then undergo hydration and are transformed into the ketones.