43200-83-5 Usage
Description
3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid, also known as 3-[[(5-Chloro-2-pyridinyl)amino]carbonyl]-2-pyrazinecarboxylic acid, is an organic compound with a chemical structure that features a pyrazine-2-carboxylic acid core, a carbamoyl group, and a 5-chloropyridin-2-yl moiety. It is an impurity found in Zopiclone, a non-benzodiazepine GABAA receptor agonist used as a sedative and hypnotic.
Uses
Used in Pharmaceutical Industry:
3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid is used as an impurity in the production of Zopiclone (Z700500), a cyclopyrrolone derivative and a member of the non-benzodiazepine GABAA receptor agonists. It serves as a controlled substance (depressant) in the United States, but not in Canada. 3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid plays a role in the sedative and hypnotic effects of Zopiclone, which are utilized for the treatment of insomnia and other sleep disorders.
In the pharmaceutical industry, the presence of this impurity in Zopiclone is carefully monitored and controlled to ensure the safety and efficacy of the medication. 3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid's role in the sedative and hypnotic effects of Zopiclone highlights its importance in the development and production of non-benzodiazepine GABAA receptor agonists for the treatment of sleep disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 43200-83-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,2,0 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 43200-83:
(7*4)+(6*3)+(5*2)+(4*0)+(3*0)+(2*8)+(1*3)=75
75 % 10 = 5
So 43200-83-5 is a valid CAS Registry Number.
43200-83-5Relevant articles and documents
Process for the preparation of eszopiclone
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Page/Page column 4-5, (2008/12/06)
The invention relates to a process for making of 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo-[3,4-b] pyrazin-5-yl-4-methyl piperazine-1-carboxylate, also known as zopiclone. The invention further describes an effective method for resolving of zopiclone into its enantiomers (eszopiclone and (R)-zopiclone) and also provides a method of recycling of (R)-zopiclone.
CYCLIC IMINOCARBAMATES AND USE THEREOF
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Page/Page column 28-29; 17, (2010/11/08)
The invention relates to novel cyclic iminocarbamates of formula (I), wherein R1, R2, R3, A, Z and n have the meaning cited in the description, to a method for the production thereof, to the use thereof for treating and/or for the prophylaxis of illnesses, and to the use thereof in the production of medicaments for treating and/or for the prophylaxis of diseases, in particular of thromboembolic diseases.
