432022-88-3 Usage
Description
4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER, also known as Methyl 4-Bromo-3,5-dimethylbenzoate, is an organic compound with the molecular formula C10H11BrO2. It is a derivative of benzoic acid, featuring a bromine atom at the 4-position, two methyl groups at the 3 and 5 positions, and a methyl ester functional group. 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER is characterized by its potential reactivity and utility in the synthesis of various chemical compounds.
Uses
Used in Pharmaceutical Industry:
4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER is used as a reagent for the preparation of benzylaminopyrazinylcyclopropanecarboxylic acid derivatives. These derivatives are employed as GPR40 receptor activity modulators, which play a crucial role in the treatment of type 2 diabetes and other related metabolic disorders. 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER's unique structure allows for the development of new drugs targeting the GPR40 receptor, potentially leading to improved therapeutic options for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 432022-88-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,2,0,2 and 2 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 432022-88:
(8*4)+(7*3)+(6*2)+(5*0)+(4*2)+(3*2)+(2*8)+(1*8)=103
103 % 10 = 3
So 432022-88-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H11BrO2/c1-6-4-8(10(12)13-3)5-7(2)9(6)11/h4-5H,1-3H3
432022-88-3Relevant articles and documents
Electro-Oxidative Selective Esterification of Methylarenes and Benzaldehydes
Yu, Congjun,?zkaya, Bünyamin,Patureau, Frederic W.
supporting information, p. 3682 - 3687 (2021/02/01)
A mild and green electro-oxidative protocol to construct aromatic esters from methylarenes and alcohols is herein reported. Importantly, the reaction is free of metals, chemical oxidants, bases, acids, and operates at room temperature. Moreover, the design of the electrolyte was found critical for the oxidation state and structure of the coupling products, a rarely documented effect. This electro-oxidative coupling process also displays exceptional tolerance of many fragile easily oxidized functional groups such as hydroxy, aldehyde, olefin, alkyne, as well as neighboring benzylic positions. The enantiomeric enrichment of some chiral alcohols is moreover preserved during this electro-oxidative coupling reaction, making it overall a promising synthetic tool.
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors
Corbett,Dirico,Song,Boscoe,Doran,Boyer,Qiu,Ammirati,VanVolkenburg,McPherson,Parker,Cox
, p. 6707 - 6713 (2008/09/17)
The cis-3-amino-4-(2-cyanopyrrolidide)-pyrrolidine template has been shown to afford low nanomolar inhibitors of human DPP-IV that exhibit a robust PK/PD profile. An X-ray co-crystal structure of 5 confirmed the proposed mode of binding. The potent single
