433228-88-7

Basic information

• Product Name: Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI)
• Synonyms: Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI);(R)-1-(3,5-Difluorophenyl)ethanol
• CAS NO: 433228-88-7
• Molecular Formula: C8H8F2O
• Molecular Weight: 158.1453264
• Product Categories: HALIDE
• Mol File: 433228-88-7.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI)(433228-88-7)
• EPA Substance Registry System: Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI)(433228-88-7)

Safety Data

• Hazardous Substances Data: 433228-88-7(Hazardous Substances Data)

Usage

General Description

Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI) is a chemical compound with a molecular formula C8H8F2O. Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI) is also known as 3,5-difluoro-alpha-methylbenzyl alcohol and is primarily used as a building block in the synthesis of various pharmaceutical and agrochemical products. It is a white solid at room temperature and is soluble in organic solvents. Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI) has asymmetric carbon and exists in the alphaR form. It is important to handle this chemical with caution as it may pose health risks if not handled properly.

Upstream product

• 123577-99-1 3′,5′-difluoroacetophenone 
• 117358-52-8 1-ethyl-3,5-difluorobenzene 
• 32085-88-4 3,5-difluorobenzaldehyde 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1586041-32-8 N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluoro-4-(1-hydroxyethyl)phenyl)thiazole-4-carboxamide 
• 1586041-41-9 N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluoro-4-((R)-1-hydroxyethyl)phenyl)thiazole-4-carboxamide 
• 1586041-42-0 N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluoro-4-((S)-1-hydroxyethyl)phenyl)thiazole-4-carboxamide 
• 1586045-23-9 2-(2,6-difluoro-4-(1-hydroxyethyl)phenyl)thiazole-4-carboxylic acid 
• 1586045-42-2 (R)-2-(2,6-difluoro-4-(1-hydroxyethyl)phenyl)thiazole-4-carboxylic acid 
• 1586045-46-6 (S)-2-(2,6-difluoro-4-(1-hydroxyethyl)phenyl)thiazole-4-carboxylic acid 
• 1403895-88-4 6-(2,6-difluoro-4-(1-hydroxyethyl)phenyl)-5-fluoropicolinic acid 
• 1586040-47-2 N-(5-((2S,5R,6R)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-6-(2,6-difluoro-4-(1-hydroxyethyl)phenyl)-5-fluoropicolinamide 
• 1586045-19-3 1-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol 
• 1620013-88-8 4-{(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-methylpiperidin-1-yl}-3-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 
• 1620013-89-9 tert-butyl ((3S,5R)-1-{3-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl}-5-methylpiperidin-3-yl)carbamate 
• 1620013-87-7 N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide 
• 123577-99-1 3′,5′-difluoroacetophenone 
• 1063733-77-6 2-(3,5-difluorophenoxy)propan-2-ol 

Relevant articles and documents

A Cobalt(II) Complex Bearing the Amine(imine)diphosphine PN(H)NP Ligand for Asymmetric Transfer Hydrogenation of Ketones

Novel chiral cobalt complex a containing amine(imine)diphosphine PN(H)NP ligand and complex b containing bis(amine)diphosphine PN(H)N(H)P ligand were synthesized. The structures of two complexes were characterized by X-ray crystallography and high resolution mass spectrometry. The catalytic performances of cobalt complexes a and b for asymmetric transfer hydrogenation (ATH) of ketones under mild conditions were evaluated using 2-propanolisopropanol as solvent and hydrogen source after being activated by 8 equivalents of base. Complex a showed a good reactivity for reduction of ketones, with a turnover number (TON) of up to 555, and a maximum enantiomeric excess (ee) value of up to 91 %. Complex b exhibited inertness for hydrogenation of ketones. Electronic structure studies on a and b were conducted to account for the function of ligands on the catalytic performances.

Enantioselective Bioamination of Aromatic Alkanes Using Ammonia: A Multienzymatic Cascade Approach

Chiral amines are common drug building blocks and important active pharmaceutical ingredients. Preparing these functionalized compounds from simple materials, such as alkanes, is of great interest. We recently developed an artificial bioamination cascade for the C?H amination of cyclic alkanes by combining P450 monooxygenase, alcohol dehydrogenase, and amine dehydrogenase. Herein, this system has been extended to the synthesis of chiral aromatic amines. In the first hydroxylation step, process optimization increased the conversion to 77 %. Two stereoselectively complementary alcohol dehydrogenases and an amine dehydrogenase were selected for the bioconversion of aromatic hydrocarbons to amines. The amination reaction was optimized with respect to cofactor addition and enzyme dosage. Isopropanol was added to decrease ketone intermediate accumulation in the amination step, which further enhanced the overall conversion. This cascade system converted a panel of hydrocarbon substrates into the corresponding amines with excellent optical purity (>99 % ee) and moderate conversion ratios (13–53 %).

FUNGICIDAL COMPOSITIONS

The present invention provides a composition comprising a combination of components A) and B), wherein component A) is a compound of formula (I) and the component (B) is a further fungicide, insecticide or herbicide.