4334-74-1

Basic information

• Product Name: [2-(4-Methoxybenzylidene)hydrazono](amino)methanethiol
• Synonyms: [2-(4-Methoxybenzylidene)hydrazono](amino)methanethiol;Anisaldehyde thiosemicarbazone;TB II/242
• CAS NO: 4334-74-1
• Molecular Formula: C₉H₁₁N₃OS
• Molecular Weight: 209.2681
• Mol File: 4334-74-1.mol
• Article Data: 72

Chemical Properties

• Boiling Point: 354.6°Cat760mmHg
• Flash Point: 168.3°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 3.3E-05mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: [2-(4-Methoxybenzylidene)hydrazono](amino)methanethiol(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-Methoxybenzylidene)hydrazono](amino)methanethiol(4334-74-1)
• EPA Substance Registry System: [2-(4-Methoxybenzylidene)hydrazono](amino)methanethiol(4334-74-1)

Safety Data

• Hazardous Substances Data: 4334-74-1(Hazardous Substances Data)

Usage

Description

[2-(4-Methoxybenzylidene)hydrazono](amino)methanethiol, also known as 4-Methoxybenzylidenehydrazone-2-aminoethanethiol, is a hydrazone derivative characterized by a substituted aromatic ring and an imine functional group. This thiol derivative has demonstrated potential antioxidant, anti-inflammatory, and antimicrobial properties, along with the possibility of serving as a chelating agent for heavy metals. Further research is essential to fully comprehend its biological and pharmaceutical potential.

Uses

Used in Pharmaceutical Applications:
[2-(4-Methoxybenzylidene)hydrazono](amino)methanethiol is used as a potential therapeutic agent for various conditions due to its demonstrated antioxidant, anti-inflammatory, and antimicrobial properties. These characteristics make it a candidate for treating a range of diseases and disorders where oxidative stress, inflammation, or microbial infections are involved.
Used in Chemical Synthesis:
In the chemical industry, [2-(4-Methoxybenzylidene)hydrazono](amino)methanethiol can be used as a building block or intermediate in the synthesis of more complex molecules with specific applications, such as pharmaceuticals, agrochemicals, or other specialty chemicals.
Used in Material Science:
[2-(4-Methoxybenzylidene)hydrazono](amino)methanethiol's chelating properties make it a potential candidate for use in material science, particularly in the development of new materials with specific properties, such as improved stability or resistance to environmental factors.
Used in Environmental Applications:
As a chelating agent for heavy metals, [2-(4-Methoxybenzylidene)hydrazono](amino)methanethiol could be employed in environmental applications to remediate contaminated sites or to prevent the accumulation of toxic metals in ecosystems.
Used in Research and Development:
Due to its unique structure and potential properties, [2-(4-Methoxybenzylidene)hydrazono](amino)methanethiol is a valuable compound for research and development in various scientific fields, including chemistry, biology, and materials science. It can be used to explore new reactions, mechanisms, and applications, contributing to the advancement of knowledge in these areas.

InChI:InChI=1/C9H11N3OS/c1-13-8-4-2-7(3-5-8)6-11-12-9(10)14/h2-6H,1H3,(H3,10,12,14)/b11-6+

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 2299-73-2 N,N-bis(4-methoxybenzylidene)hydrazine 
• 79-19-6 thiosemicarbazide 
• 2286-29-5 ethyl 2-cyano-3-(4-methoxyphenyl)prop-2-enoate 
• 78255-58-0 2,4-bis(p-methoxyphenyl)-3-azabicyclo<3.3.1>nonan-9-one 
• 4346-94-5 thiosemicarbazide hydrochloride 
• 2290-65-5 trimethylsilyl isothiocyanate 
• 5953-85-5 p-anisaldehyde hydrazone 

Downstream Products

• 99844-05-0 4-methoxy-benzaldehyde-thiazol-2-ylhydrazone 
• 103726-45-0 5-methyl-thiazolidine-2,4-dione-2-(4-methoxy-benzylidenehydrazone) 
• 1014-25-1 5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-ylamine 
• 874-90-8 4-methoxybenzonitrile 
• 109566-85-0 5-(2-chloro-benzylidene)-thiazolidine-2,4-dione-2-(4-methoxy-benzylidenehydrazone) 
• 3673-32-3 2-(4-methoxybenzylidene)hydrazino-4-methylthiazole 
• 6320-51-0 5-(4-methoxybenzylidene)thiazolidine-2,4-dione 
• 36951-42-5 (2-(4-methoxyphenyl)methylene)hydrazolyl-1,3-thiazolidin-4-one 
• 108170-28-1 4-methoxy-benzaldehyde (5-butyl-4-oxo-thiazolidin-2-ylidene)-hydrazone 
• 109251-46-9 4-methoxy-benzaldehyde [4-(4-bromo-phenyl)-5-oxo-thiazolidin-2-ylidene]-hydrazone 
• 109393-58-0 4-methoxy-benzaldehyde [4-(2,4-dichloro-phenyl)-5-oxo-thiazolidin-2-ylidene]-hydrazone 
• 62236-07-1 N-(4-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 
• 78559-89-4 2-[2-(4-methoxybenzylidene)hydrazinyl]-4-phenyl-1,3-thiazole 
• 136513-93-4 2-{N'-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-hydrazino}-thiazole-4-carboxylic acid; hydrobromide 

Relevant articles and documents

Spectroscopic and biological approach of Ni(II), Cu(II) and Co(II) complexes of 4-methoxy/ethoxybenzaldehyde thiosemicarbazone glyoxime

Two novel vicinal dioxime ligands containing (4-methoxybenzaldehyde thiosemicarbazone glyoxime (L1H2) or 4-ethoxybenzaldehyde thiosemicarbazone glyoxime (L2H2)) thiosemicarbazone units were synthesized and characterized using 1H NMR, 13C NMR, HMQC, MS, infrared and, UV-VIS. spectroscopy, elemental analysis, and magnetic susceptibility measurements. Mononuclear nickel(II), copper(II) and cobalt(II) complexes with a metal:ligand ratio of 1:2 for L1H2 and L2H2 were also synthesized. The effect of pH and solvent on the absorption spectra of both ligands and complexes was determined. IR spectra show that the ligands act in a bidentate manner and coordinates N 4 donor groups of the ligands to NiII, CuII and CoII ions. The detection of H-bonding (O-H?O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of mononuclear complexes. The antimicrobial activities of compounds L1H2, L2H2, and their Ni(II), Cu(II) and Co(II) complexes were evaluated using the disc diffusion method against 12 bacteria and 4 yeasts. The minimal inhibitory concentrations (MICs) against 7 bacteria and 3 yeasts were also determined. Among the test compounds attempted, L1H2, [Ni(L 1H)2], [Cu(L1H)2], L 2H2, [Ni(L2H)2] and [Cu(L 2H)2] showed some activities against certain Gram-positive bacteria and some of the yeasts tested.

Synthesis, antimicrobial and antioxidant evaluation with in silico studies of new thiazole Schiff base derivatives

A series of nineteen thiazole Schiff base derivatives 2a-2s were synthesized (Scheme 1) and elucidated by spectral analyses (IR, 1H NMR and HRMS). The evaluation of their antimicrobial activities against two gram-positive, two gram-negative, an

Effect of organic solvents on solvatochromic, fluorescence, and electrochemical properties of synthesized thiazolylcoumarin derivatives

In this present investigation, thiazolylcoumarin derivatives (5a–5k) were synthesized from thiosemicarbazide, ethyl acetoacetate, and naphthaldehyde through a multistep route. The formation of thiazolylcoumarin derivatives with bioactive scaffolds was con

Synthesis of Emodin Amide Derivatives Containing 1,3,4-Thiadiazole and Their Inhibitory Activity on Vibrio harveyi

A series of new 1,3,4-thiadiazole Emodin amide derivatives were synthesized through the connection of 5-substituted-1,3,4-thiadiazole-2-amine and Emodin carboxylic acids which were obtained by a two-step procedure starting from Emodin. Vibrio harveyi inhibition activities of the newly prepared compounds were evaluated. Results revealed that all compounds showed different degrees of inhibition on V. harveyi. Among them, compound 7a showed the best V. harveyi inhibition effect and the minimum inhibitory concentration (MIC) was 0.0625 mg/mL.