4336-20-3

Basic information

• Product Name: Dimethyl1,6-hexanedicarboxylate
• Synonyms: Nsc401685
• CAS NO: 4336-20-3
• Molecular Formula: C₁₀H₁₆O₄
• Molecular Weight: 200.2316
• Mol File: 4336-20-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 259°Cat760mmHg
• Flash Point: 121.3°C
• Appearance: /
• Density: 1.102g/cm³
• CAS DataBase Reference: Dimethyl1,6-hexanedicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Dimethyl1,6-hexanedicarboxylate(4336-20-3)
• EPA Substance Registry System: Dimethyl1,6-hexanedicarboxylate(4336-20-3)

Safety Data

• Hazardous Substances Data: 4336-20-3(Hazardous Substances Data)

Upstream product

• 60719-11-1 2-Carboethoxy-7-chlorocycloheptanon 
• 186581-53-3 diazomethane 
• 2495-35-4 benzylacrylate 
• 2409-87-2 methyl (2E)-penta-2,4-dienoate 
• 1732-09-8 dimethyl subarate 
• 29516-56-1 Z-2-carbo-tert-perbutoxy cyclohexanecarboxylic acid 
• 29516-56-1 E-2-carbo-tert-perbutoxy cyclohexanecarboxylic acid 
• 67-56-1 methanol 
• 13149-00-3 1,2-cis-cyclohexanedicarboxylic anhydride 
• 14166-21-3 (+/-)-trans-1,2-cyclohexanedicarboxylic anhydride 
• 1687-30-5 cyclohexane-1,2-dicarboxylic acid 
• 74-88-4 methyl iodide 
• 7500-55-2 dimethyl cyclohex-4-ene-1,2-dicarboxylate 
• 131-11-3 phthalic acid dimethyl ester 

Downstream Products

• 32003-11-5 cyclohexane-1,2-dicarboxylic acid dihydrazide 
• 41902-36-7 1,2-dimethyl cyclohex-2-ene-1,2-dicarboxylate 
• 4336-19-0 1,2-dimethyl cyclohex-1-ene-1,2-dicarboxylate 
• 88335-92-6 (1S,2R)-2-(methoxycarbonyl)cyclohexanecarboxylic acid 
• 88335-91-5 cyclohexane-1,2-dicarboxylic acid monomethyl ester 
• 72039-99-7 C₁₀H₁₄O₄^(2-)*2Li⁽¹⁺⁾ 
• 7719-08-6 trans-1,2-cyclohexanedicarboxylic acid,monomethyl ester 
• 83248-48-0 1,2-Dimethyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester 
• 65376-02-5 (1S,6R)-8-oxabicyclo[4.3.0]nonan-7-one 
• 213993-31-8 (1S,2S)-2-amino-cyclohexylmethanol 
• 144478-67-1 ((1S,2S)-2-Hydroxymethyl-cyclohexylamino)-acetonitrile 
• 116174-40-4 (1S,2S)-2-Hydroxymethyl-cyclohexanecarboxylic acid amide 
• 116174-39-1 ((1S,2S)-2-Hydroxymethyl-cyclohexyl)-pyrrolidin-1-yl-methanone 
• 1158650-42-0 N-Cyanomethyl-N-((1S,2S)-2-hydroxymethyl-cyclohexyl)-benzamide 

Relevant articles and documents

PRODUCTION METHOD OF CYCLIC COMPOUND

PROBLEM TO BE SOLVED: To provide an industrially simple production method of a cyclic compound. SOLUTION: A production method of a cyclic compound includes a step to obtain a reduced form (B) by reducing an unsaturated bond in a ring structure of an aromatic compound (A) by means of catalytic hydrogenation of the aromatic compound (A) or its salt using palladium carbon as a catalyst under a normal pressure, in which the aromatic compound (A) has one or more ring structures selected from a group consisting of a five membered-ring, a six membered-ring, and a condensed ring of the five membered-ring or the six membered-ring with another six membered-ring, a hetero atom can be included in the ring structure, and the aromatic compound (A) can have one or two side chains bonded to the ring structure and does not have any carbon-carbon triple bond in the side chain. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Synthetic method of alicyclic diester

The invention discloses a synthetic method of alicyclic diester. The synthetic method comprises the following steps: enabling diacid comprising a multi-carbon lipid chain end group or diester containing a multi-carbon lipid chain end group to react with a first halogenation reagent, after the reaction is completed, adding a second halogenation reagent into a reaction product, after the reaction iscompleted, re-esterifying, and obtaining the di-ester of di-halogenation; adding the di-ester of the di-halogenation into an organic solvent, adding alkali to perform the reaction, after the reactionis completed, adding acid to perform the neutralization, and obtaining annular di-ester; and performing the reduction reaction for the annular di-ester, and obtaining the alicyclic diester. By adopting the synthetic method, a novel reaction path is developed, and the direct-chain end-group diacid or diester is used as a raw material to prepare the alicyclic diester by virtue of bromination reaction, ring-closing reaction and the reduction reaction. The initial raw material is low in cost, the process is simple, the reaction condition requirement is low, the safety is good, the product yield and purity are high, and the mass production is easy to realize. Moreover, the diester of a three-membered ring to an eighteen-membered ring can be prepared by utilizing the synthetic method of the invention.

Structure-activity relationships of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase

Structure-activity relationships of cycloalkylamide compounds as inhibitors of human sEH were investigated. When the left side of amide function was modified by a variety of cycloalkanes, at least a C6 like cyclohexane was necessary to yield reasonable inhibition potency on the target enzyme. In compounds with a smaller cycloalkane or with a polar group on the left side of amide function, no inhibition was observed. On the other hand, increased hydrophobicity dramatically improved inhibition potency. Especially, a tetrahydronaphthalene (20) effectively increased the potency. When a series of alkyl or aryl derivatives of cycloalkylamide were investigated to continuously optimize the right side of the amide pharmacophore, a benzyl moiety functionalized with a polar group produced highly potent inhibition. A nonsubstituted benzyl, alkyl, aryl, or biaryl structure present on the right side of the cycloalkylamide function induced a big decrease in inhibition potency. Also, the resulting potent cycloalkylamide (32) showed reasonable physical properties.