4336-46-3 Usage
Description
1-(DiaMinoMethylene)-3-(beta-D-ribofuranosyl)urea Picrate, also known as Azacitidine Picrate, is a chemical compound derived from Azacitidine. It is characterized by its unique structure, which includes a diaminomethylene group and a beta-D-ribofuranosyl group attached to a urea molecule. 1-(DiaMinoMethylene)-3-(beta-D-ribofuranosyl)urea Picrate exhibits properties that make it a potential candidate for various applications in the pharmaceutical and medical fields.
Uses
Used in Pharmaceutical Industry:
1-(DiaMinoMethylene)-3-(beta-D-ribofuranosyl)urea Picrate is used as a DNA methyltransferase (DNMT) inhibitor for the treatment of myelodysplastic syndromes (MDS). It works by inhibiting the activity of DNMTs, which are enzymes responsible for adding methyl groups to DNA, thereby altering gene expression. This inhibition leads to the reactivation of silenced genes and the suppression of cancer cell growth.
Additionally, 1-(DiaMinoMethylene)-3-(beta-D-ribofuranosyl)urea Picrate may be used in combination with other chemotherapeutic agents to enhance their efficacy and overcome drug resistance in cancer treatment. Its synergistic effects with conventional drugs can improve chemo-sensitivity and therapeutic outcomes in patients with various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 4336-46-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,3 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4336-46:
(6*4)+(5*3)+(4*3)+(3*6)+(2*4)+(1*6)=83
83 % 10 = 3
So 4336-46-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H14N4O5.C6H3N3O7/c8-6(9)11-7(15)10-5-4(14)3(13)2(1-12)16-5;10-6-4(8(13)14)1-3(7(11)12)2-5(6)9(15)16/h2-5,12-14H,1H2,(H5,8,9,10,11,15);1-2,10H
