4338-65-2

Basic information

• Product Name: 3-(4-methylbenzyl)dihydrofuran-2,5-dione
• Synonyms: 3-(4-methylbenzyl)dihydrofuran-2,5-dione
• CAS NO: 4338-65-2
• Molecular Weight: 204.225
• Mol File: 4338-65-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(4-methylbenzyl)dihydrofuran-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methylbenzyl)dihydrofuran-2,5-dione(4338-65-2)
• EPA Substance Registry System: 3-(4-methylbenzyl)dihydrofuran-2,5-dione(4338-65-2)

Safety Data

• Hazardous Substances Data: 4338-65-2(Hazardous Substances Data)

Upstream product

• 502610-55-1 diethyl 2-acetyl-2-(4-methylbenzyl)succinate 
• 4484-74-6 4-methylbenzyl iodide 
• 6315-21-5 2-(4-methylbenzyl)succinic acid 
• 108-31-6 maleic anhydride 
• 106-42-3 para-xylene 

Downstream Products

• 109393-68-2 7-Methyl-1-phenyl-3-hydroxymethyl-3,4-dihydro-naphthalin 
• 110180-43-3 7-Methyl-1-phenyl-2,3-methylen-tetralol-⁽¹⁾ 
• 101742-95-4 7-Methyl-3-hydroxymethyl-1-phenyl-tetralin 
• 110048-14-1 7-methyl-3-(toluene-4-sulfonyloxymethyl)-3,4-dihydro-2H-naphthalen-1-one 
• 109556-42-5 Phenylurethan des 5-Hydroxy-3-methyl-6.7-dihydro-5H-benzocycloheptens 
• 102156-40-1 Phenylurethan des 6-Hydroxy-2.9-dimethyl-6.7.8.9-tetrahydro-5H-benzocycloheptens 
• 102597-06-8 Phenylurethan des 6-Hydroxy-2-methyl-9-aethyl-6.7.8.9-tetrahydro-5H-benzocycloheptens 
• 102012-30-6 Phenylurethan des 6-Hydroxy-2.9-dimethyl-6.7-dihydro-5H-benzocycloheptens 
• 111719-45-0 Phenylurethan des 6-Hydroxy-2-methyl-9-aethyl-6.7-dihydro-5H-benzocycloheptens 
• 101794-65-4 6-methyl-1,2,3,4-tetrahydro-[2]naphthaldehyde-(2,4-dinitro-phenylhydrazone) 

Relevant articles and documents

INDANE DERIVATIVES FOR MALODOR COUNTERACTION

The present invention relates to the field of malodor counteraction. More particularly, it concerns malodor masking ingredient having an indane moiety (as defined in formula (I)), as well as malodor masking compositions comprising such ingredients.

A practical procedure for the synthesis of esonarimod, (R,S)-2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid, an antirheumatic agent (part 1).

An efficient and practical procedure for the synthesis of esonarimod, (R,S)-2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (1), a new antirheumatic drug, has been developed. The intermediate, 2-methylene-4-(4-methylphenyl)-4-oxobutanoic acid (2), was prepared by Friedel-Crafts acylation of toluene with itaconic anhydride (3) in the presence of aluminum trichloride and nitrobenzene in 63% yield without silica gel column purification. Compound 1 was prepared by Michael addition of 2 with thioacetic acid (4) in 74% yield. Overall, 1 was obtained in 47% yield from 3. The structures and synthetic mechanisms of by-products (five compounds) of 2 were also clarified.