433939-98-1

Basic information

• Product Name: 1-Azetidinecarboxylic acid, 2-[[[[2,6-difluoro-4-[imino[[[2-(trimethylsilyl)ethoxy]carbonyl]amino]methyl ]phenyl]methyl]amino]carbonyl]-, 1,1-dimethylethyl ester, (2S)-
• CAS NO: 433939-98-1
• Molecular Formula: C23H34F2N4O5Si
• Molecular Weight: 512.629
• Mol File: 433939-98-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Azetidinecarboxylic acid, 2-[[[[2,6-difluoro-4-[imino[[[2-(trimethylsilyl)ethoxy]carbonyl]amino]methyl ]phenyl]methyl]amino]carbonyl]-, 1,1-dimethylethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Azetidinecarboxylic acid, 2-[[[[2,6-difluoro-4-[imino[[[2-(trimethylsilyl)ethoxy]carbonyl]amino]methyl ]phenyl]methyl]amino]carbonyl]-, 1,1-dimethylethyl ester, (2S)-(433939-98-1)
• EPA Substance Registry System: 1-Azetidinecarboxylic acid, 2-[[[[2,6-difluoro-4-[imino[[[2-(trimethylsilyl)ethoxy]carbonyl]amino]methyl ]phenyl]methyl]amino]carbonyl]-, 1,1-dimethylethyl ester, (2S)-(433939-98-1)

Safety Data

• Hazardous Substances Data: 433939-98-1(Hazardous Substances Data)

Upstream product

• 51077-14-6 (S)-1-(t-butoxycarbonyl)azetidine-2-carboxylic acid 
• 433939-97-0 Boc-Pab(2,6-diF)(Teoc) 
• 433939-97-0 Boc-Pab(2,6-diF)(Teoc) 

Downstream Products

• 433939-99-2 Ph(3-Cl)(5-OCHF₂)-(R)CH(OH)C(O)-Aze-Pab(2,6-diF)(Teoc) 
• 433939-99-2 Ph(3-Cl)(5-OCHF₂)-(R)-CH(OH)C(O)-Aze-Pab(2,6-diF)(Teoc) 
• 433939-99-2 Ph(3-Cl)(5-OCHF₂)-(R)CH(OH)C(O)-Aze-Pab(2,6-diF)(Teoc) 

Relevant articles and documents

Mandelic acid derivatives and their use as throbin inhibitors

There is provided a compound of formula I wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

NEW SALTS

There is provided pharmaceutically-acceptable acid addition salts of compounds of formula (I), wherein R1 represents C1-2 alkyl substituted by one or more fluoro substituents; R2 represents C1-2 alkyl; and n rep

MODIFIED RELEASE PHARMACEUTICAL FORMULATION

A modified release pharmaceutical composition comprising, as active ingredient, a compound of formula (I), wherein R1 represents C?1-2#191 alkyl substituted by one or more fluoro substituents;R2 represents hydrogen, hydroxy, methoxy