433958-47-5

Basic information

• Product Name: 3-Pyridinecarbonitrile, 2-amino-6-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-4-(3-nitrophen yl)-
• CAS NO: 433958-47-5
• Molecular Formula: C24H26N4O3Si
• Molecular Weight: 446.581
• Mol File: 433958-47-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarbonitrile, 2-amino-6-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-4-(3-nitrophen yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonitrile, 2-amino-6-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-4-(3-nitrophen yl)-(433958-47-5)
• EPA Substance Registry System: 3-Pyridinecarbonitrile, 2-amino-6-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-4-(3-nitrophen yl)-(433958-47-5)

Safety Data

• Hazardous Substances Data: 433958-47-5(Hazardous Substances Data)

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 120820-40-8 1-(2-(((1,1-dimethylethyl)dimethylsilyl)oxy)phenyl)ethanone 
• 109-77-3 malononitrile 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 120131-35-3 2-[1-(3-nitrophenyl)ethylidene]-malononitrile 

Downstream Products

• 433958-46-4 2-amino-4-(3-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)nicotinonitrile 
• 433958-64-6 2-amino-4-(3-aminophenyl)-6-(2-hydroxyphenyl)nicotinonitrile 
• 433957-83-6 N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide 
• 433958-58-8 N-{3-[2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-cyano-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide 
• 433958-86-2 N-{3-[2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-cyano-4-pyridinyl]phenyl}-3-(1-piperidinyl)propanamide 
• 925921-61-5 N-[6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-cyano-4-(3-nitrophenyl)pyridin-2-yl]thiophene-2-carboxamide 
• 925924-14-7 N-[6-(2-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-cyano-4-(3-nitrophenyl)pyridin-2-yl]benzamide 

Relevant articles and documents

Cu(OAc)2/DABCO-mediated domino reaction of vinyl malononitriles with cyclic sulfamidate imines: access to 6-hydroxyaryl-2-aminonicotinonitriles

A novel Cu(ii)–salt/DABCO-mediated one-pot access to a myriad of highly substituted biologically relevant 2-aminonicotinonitriles possessing a resourceful phenolic moiety with satisfactory yields is reported. This method involves cyclic sulfamidate imines as 1C1N sources and different kinds of acyclic/cyclic vinyl malononitriles as 4C sources for pyridine synthesis via a vinylogous Mannich-cycloaromatization sequence process, creating two new C–N bonds under mild conditions. Importantly, this de novo strategy is applicable to gram-scale syntheses, underlining the method's practicability and allowing for a wide range of substrates with excellent functional group tolerance.

Discovery of novel and selective IKK-β serine-threonine protein kinase inhibitors. Part 1

IκB kinase β (IKK-β) is a serine-threonine protein kinase critically involved in the activation of the transcription factor Nuclear Factor kappa B (NF-κB) in response to various inflammatory stimuli. We have identified a small molecule inhibitor of IKK-β. Optimization of the lead compound resulted in improvements in both in vitro and in vivo potency, and provided IKK-β inhibitors exhibiting potent activity in an acute cytokine release model (LPS-induced TNFα).