4361-44-8

Basic information

• Product Name: 3-CYCLOHEXYL-PROPYLAMINE
• Synonyms: 3-CYCLOHEXYL-PROPYLAMINE;CyclohexanepropanaMine
• CAS NO: 4361-44-8
• Molecular Formula: C₉H₁₉N
• Molecular Weight: 141.25
• Mol File: 4361-44-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 191.846 °C at 760 mmHg
• Flash Point: 64.68 °C
• Appearance: /
• Density: 0.86 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-CYCLOHEXYL-PROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CYCLOHEXYL-PROPYLAMINE(4361-44-8)
• EPA Substance Registry System: 3-CYCLOHEXYL-PROPYLAMINE(4361-44-8)

Safety Data

• Hazardous Substances Data: 4361-44-8(Hazardous Substances Data)

Usage

General Description

3-Cyclohexyl-propylamine is an organic compound that belongs to the class of amines, which are organic compounds that contain a basic nitrogen atom. This chemical is used in the production of pharmaceuticals, herbicides, and corrosion inhibitors. It is also utilized in the synthesis of various other organic compounds. 3-Cyclohexyl-propylamine is a colorless liquid with a slightly amine-like odor and is considered to be a moderately hazardous chemical. It is important to handle and store this chemical with caution, following proper safety protocols to prevent any potential harm or accidents.

Upstream product

• 41010-09-7 3-cyclohexylpropionitrile 
• 144290-77-7 N-[3-cyclohexylprop-1-yl]phthalimide 
• 1124-62-5 3-cyclohexylpropyl chloride 
• 1124-63-6 3-cyclohexylpropan-1-ol 
• 34094-21-8 (3-bromopropyl)cyclohexane 
• 80053-69-6 cyclohexanone oxime methanesulfonate 
• 100-64-1 cyclohexanone-oxime 
• 3338-05-4 2-Propyl-1-aza-cyclohept-1-en 
• 701-97-3 cyclohexanepropionic acid 
• 39098-75-4 3-cyclohexylpropionyl chloride 
• 4361-29-9 3-cyclohexylpropanamide 

Downstream Products

• 124499-02-1 (2R,3R,4S,5R)-2-[6-Amino-2-(3-cyclohexyl-propylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol 
• 76210-61-2 1-(3-Cyclohexyl-propylamino)-3-phenoxy-propan-2-ol; hydrochloride 
• 1027903-93-0 [(S)-5-tert-Butoxycarbonylamino-5-(3-cyclohexyl-propylcarbamoyl)-pentyl]-carbamic acid benzyl ester 
• 1025966-12-4 [(S)-5-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-5-(3-cyclohexyl-propylcarbamoyl)-pentyl]-carbamic acid benzyl ester 
• 1026387-78-9 [(S)-5-[(S)-2-(11-Azido-undecanoylamino)-3-benzyloxy-propionylamino]-5-(3-cyclohexyl-propylcarbamoyl)-pentyl]-carbamic acid benzyl ester 
• 144290-65-3 N-Benzoyl-N'-(3-cyclohexyl-propyl)-N''-[3-(1H-imidazol-4-yl)-propyl]-guanidine 
• 144478-16-0 N-(3-Cyclohexyl-propyl)-N'-[3-(1H-imidazol-4-yl)-propyl]-guanidine; hydrochloride 
• 1048974-13-5 C₂₃H₃₀N₄O₂ 
• 1150267-72-3 C₂₉H₂₉F₃N₄O₂ 
• 1192559-67-3 1-cyano-3-(3-cyclohexylpropyl)-2-phenylisourea 
• 1243599-71-4 C₁₅H₂₁N₃O₆S 
• 454646-67-4 3-(1H-imidazol-4-yl)propyl 3-cyclohexylpropylcarbamate hydrogen maleate 
• 93489-29-3 C₁₀H₁₇NO 

Relevant articles and documents

Remote Regioselective Radical C-H Functionalization of Unactivated C-H Bonds in Amides: The Synthesis of gem-Difluoroalkenes

The site-selective functionalization of unactivated aliphatic amines is an attractive and challenging synthetic approach. We herein report a general strategy for the remote site-selective functionalization of unactivated C(sp3)-H bonds in amides by photogenerated amidyl radicals to form gem-difluoroalkenes with trifluoromethyl-substituted alkenes. The site selectivity is controlled by a 1,5-hydrogen atom transfer (HAT) process of the amide. This photocatalyzed transformation shows both chemo- and site-selectivity, facilitating the formation of a secondary, tertiary, or quaternary carbon center.

Remote Directed Isocyanation of Unactivated C(sp3)-H Bonds: Forging Seven-Membered Cyclic Ureas Enabled by Copper Catalysis

Reported herein is an unprecedented copper-catalyzed site-selective ?-C(sp3)-H bonds activation of aliphatic sulfonamides for constructing the synthetically useful seven-membered N-heterocycles. A key to success is the use of in-situ-formed amide radicals, to activate the inert C(sp3)-H bond, and inexpensive TMSNCO, as a coupling reagent under mild conditions. To the best of our knowledge, this represents the first use of alkylamine derivatives as a five-membered synthon to prepare a seven-membered N-heterocycles.

Exploration of flexible phenylpropylurea scaffold as novel cardiac myosin activators for the treatment of systolic heart failure

A series of flexible urea derivatives have been synthesized and demonstrated as selective cardiac myosin ATPase activator. Among them 1-phenethyl-3-(3-phenylpropyl)urea (1, cardiac myosin ATPase activation at 10?μM?=?51.1%; FS?=?18.90; EF?=?12.15) and 1-benzyl-3-(3-phenylpropyl)urea (9, cardiac myosin ATPase activation?=?53.3%; FS?=?30.04; EF?=?18.27) showed significant activity in?vitro and in?vivo. The change of phenyl ring with tetrahydropyran-4-yl moiety viz., 1-(3-phenylpropyl)-3-((tetrahydro-2H-pyran-4-yl)methyl)urea (14, cardiac myosin ATPase activation?=?81.4%; FS?=?20.50; EF?=?13.10), and morpholine moiety viz., 1-(2-morpholinoethyl)-3-(3-phenylpropyl)urea (21, cardiac myosin ATPase activation?=?44.0%; FS?=?24.79; EF?=?15.65), proved to be efficient to activate the cardiac myosin. The potent compounds 1, 9, 14 and 21 were found to be selective for cardiac myosin over skeletal and smooth myosins. Thus, these urea derivatives are potent scaffold to develop as a newer cardiac myosin activator for the treatment of systolic heart failure.