436850-19-0

Basic information

• Product Name: 1-(3-methyl-(4H)-5-phenylimidazo[2,1-b]thiazol-2-yl)ethylidenemalononitrile
• Synonyms: 1-(3-methyl-(4H)-5-phenylimidazo[2,1-b]thiazol-2-yl)ethylidenemalononitrile
• CAS NO: 436850-19-0
• Molecular Weight: 304.375
• Mol File: 436850-19-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-methyl-(4H)-5-phenylimidazo[2,1-b]thiazol-2-yl)ethylidenemalononitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-methyl-(4H)-5-phenylimidazo[2,1-b]thiazol-2-yl)ethylidenemalononitrile(436850-19-0)
• EPA Substance Registry System: 1-(3-methyl-(4H)-5-phenylimidazo[2,1-b]thiazol-2-yl)ethylidenemalononitrile(436850-19-0)

Safety Data

• Hazardous Substances Data: 436850-19-0(Hazardous Substances Data)

Upstream product

• 107922-02-1 1-(3-methyl-6-phenylimidazo[2,1-b][1,3]thiazol-2-yl)ethanone 
• 109-77-3 malononitrile 
• 70-11-1 α-bromoacetophenone 
• 30748-47-1 5-acetyl-4-methylthiazole-2-amine 

Relevant articles and documents

Synthesis of new pyridazin-6-ones, pyridazin-6-imines, 4-pyridazinals, and pyridines

3-Dimethyl-1-[3-methyl-(4H)-5-phenylimidazol[2,1-b]thiazol-2-yl]prop-2-enone 4 couples smoothly with benzenediazonium chloride to yield propanal 5 which is a key intermediate for the synthesis of pyridazinones 9-13, 16 and pyridazine-6-imine 8, 19. Pentadienonitrile 18 was converted into pyridine-3-carbonitrile 20 on refluxing in ethanolic sodium ethoxide solution. Pyrazole 24 was synthesized from the reaction of 5 with 1-chloro-2-phenylhydrazono propan-2-one 22.