4376-19-6

Basic information

• Product Name: MONOPROPYLPHTHALATE
• Synonyms: MONOPROPYLPHTHALATE;1,2-Benzenedicarboxylic Acid 1-Propyl Ester;1,2-Benzenedicarboxylic Acid Monopropyl Ester;NSC 309966;Phthalic Acid Monopropyl Ester;Phthalic Acid Propyl Ester
• CAS NO: 4376-19-6
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 206
• Product Categories: Aromatics;Metabolites & Impurities
• Mol File: 4376-19-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 351.2°C at 760 mmHg
• Flash Point: 136.6°C
• Appearance: /
• Density: 1.204g/cm³
• Vapor Pressure: 1.55E-05mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: MONOPROPYLPHTHALATE(CAS DataBase Reference)
• NIST Chemistry Reference: MONOPROPYLPHTHALATE(4376-19-6)
• EPA Substance Registry System: MONOPROPYLPHTHALATE(4376-19-6)

Safety Data

• Hazardous Substances Data: 4376-19-6(Hazardous Substances Data)

Usage

Description

MONOPROPYLPHTHALATE is a phthalate ester metabolite that is used in research to study the role of peroxisome proliferator-activated receptor (PPAR) in the mediating effects of phthalates and their metabolites in the liver. It is also known for its potential testicular toxicity.

Uses

Used in Pharmaceutical Research:
MONOPROPYLPHTHALATE is used as a research compound for studying the role of peroxisome proliferator-activated receptor (PPAR) in the liver. This helps scientists understand the effects of phthalates and their metabolites on liver function and overall health.
Used in Toxicological Studies:
MONOPROPYLPHTHALATE is used in toxicological research to investigate its potential testicular toxicity. This is important for understanding the potential health risks associated with exposure to phthalates and their metabolites.
Used in Environmental Studies:
MONOPROPYLPHTHALATE is also used in environmental studies to assess the presence and impact of phthalates in the environment. This helps in developing strategies for reducing exposure to these chemicals and mitigating their potential harmful effects on ecosystems and human health.

InChI:InChI=1/C11H12O4/c1-2-7-15-11(14)9-6-4-3-5-8(9)10(12)13/h3-6H,2,7H2,1H3,(H,12,13)

Upstream product

• 71-23-8 propan-1-ol 
• 85-44-9 phthalic anhydride 
• 131-16-8 di-n-propyl phthalate 

Relevant articles and documents

Synthesis of New Dialkyl 2,2′-[Carbonyl bis (azanediyl)]dibenzoates via Curtius Rearrangement

The 2-(alkylcarbonyl)benzoic acids obtained by esterification of phthalic anhydride are converted into azide derivatives: alkyl 2-[(azidocarbonyl)amino]benzoates and to ureas: dialkyl 2,2′-[carbonyl bis (azanediyl)]dibenzoates. These transformations were carried out using classical Curtius rearrangement conditions in the presence of diphenylphosphoryl azide (DPPA) in a basic medium, followed by hydrolysis. Subsequently, a final condensation reaction of these urea derivatives enabled us to obtain, for the first time, the new alkyl derivatives, alkyl 2-[2,4-dioxo-1,2-dihydroquinazolin-3(4 H)-yl]benzoates. All the new compounds obtained in satisfactory yields were characterized by 1H and 13C NMR, and by X-ray crystallographic analysis.

Practical selective monohydrolysis of bulky symmetric diesters: Comparing with sonochemistry

The conditions of the practical selective monohydrolysis of symmetric diesters we previously reported have been modified and applied to selective monohydrolysis of bulky symmetric diesters. While ultrasound is generally considered effective for two-phase reactions, its effect actually turned out to be rather marginal. Instead, use of a larger proportion of a polar aprotic co-solvent, DMSO, and aqueous KOH helped enhance the reaction rates and improve the yields of the half-esters. The reactions are simple, mild and practical without special devices.