4378-00-1Relevant articles and documents
Generation of α,β-unsaturated platinum carbenes from homopropargylic alcohols: Rearrangements to polysubstituted furans
Allegretti, Paul A.,Ferreira, Eric M.
, p. 5924 - 5927 (2011/12/16)
A number of diversely substituted furans are synthesized via a cycloisomerization process that goes through a unique metal carbene species. Both ligand structure and the nature of the leaving group are evaluated. The characteristics of the carbene intermediate can be modulated, resulting in highly selective hydrogen or silicon group migrations.
Spirocyclic NK1 antagonists I: [4.5] and [5.5]-Spiroketals
Seward, Eileen M,Carlson, Emma,Harrison, Timothy,Haworth, Karen E.,Herbert, Richard,Kelleher, Fintan J.,Kurtz, Marc M.,Moseley, Jonathan,Owen, Simon N.,Owens, Andrew P.,Sadowski, Sharon J.,Swain, Christopher J.,Williams, Brian J.
, p. 2515 - 2518 (2007/10/03)
A series of novel spiroketal-based NK1 antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.
