437998-39-5

Basic information

• Product Name: 2-(4-bromo-butyrylamino)-6-fluoro-benzamide
• Synonyms: 2-(4-bromo-butyrylamino)-6-fluoro-benzamide
• CAS NO: 437998-39-5
• Molecular Weight: 303.131
• Mol File: 437998-39-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-bromo-butyrylamino)-6-fluoro-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromo-butyrylamino)-6-fluoro-benzamide(437998-39-5)
• EPA Substance Registry System: 2-(4-bromo-butyrylamino)-6-fluoro-benzamide(437998-39-5)

Safety Data

• Hazardous Substances Data: 437998-39-5(Hazardous Substances Data)

Upstream product

• 927-58-2 4-bromobutyroyl chloride 
• 115643-59-9 2-amino-6-fluorobenzamide 

Downstream Products

• 437998-58-8 2-fluoro-6-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyrylamino]-benzamide 

Relevant articles and documents

Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase

A novel class of quinazolinone derivatives as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors has been discovered. Key to success was application of a rational discovery strategy involving structure-based design, combinatorial chemistry, and classical SAR for improvement of potency and bioavailability. The new inhibitors were shown to bind to the nicotinamide-ribose binding site (NI site) and the adenosine-ribose binding site (AD site) of NAD+.