438565-33-4

Basic information

• Product Name: [3-(2-CHLORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL
• Synonyms: [3-(2-CHLORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL;[3-(2-CHLOROPHENYL)-5-ISOXAZOLYL]METHANOL;3-(2-Chlorophenyl)-5-(hydroxymethyl)isoxazole;(4-(2-chlorophenyl)isoxazol-5-yl)Methanol;3-(2-Chlorophenyl)-5-isoxazoleMethanol
• CAS NO: 438565-33-4
• Molecular Formula: C₁₀H₈ClNO₂
• Molecular Weight: 209.63
• Mol File: 438565-33-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 73-76°C
• Boiling Point: 370.5°Cat760mmHg
• Flash Point: 177.9°C
• Appearance: /
• Density: 1.339g/cm³
• Vapor Pressure: 3.83E-06mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: 2-8°C
• CAS DataBase Reference: [3-(2-CHLORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(2-CHLORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL(438565-33-4)
• EPA Substance Registry System: [3-(2-CHLORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL(438565-33-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 438565-33-4(Hazardous Substances Data)

Usage

General Description

[3-(2-chloro-phenyl)-isoxazol-5-yl]-methanol is an organic compound with the molecular formula C10H8ClNO2. It is a white crystalline solid with a molecular weight of 211.63 g/mol. The compound is a derivative of isoxazole and contains a chlorophenyl group. It is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active compounds. The compound has potential applications in the development of pharmaceuticals, agrochemicals, and materials science. Its chemical properties and structure make it a valuable tool for the development of new chemical entities.

InChI:InChI=1/C10H8ClNO2/c11-9-4-2-1-3-8(9)10-5-7(6-13)14-12-10/h1-5,13H,6H2

Upstream product

• 107-19-7 propargyl alcohol 
• 29568-74-9 2-chloro-N-hydroxybenzimidoyl chloride 
• 3717-26-8 (E)-2-chlorobenzaldehyde oxime 
• 1193-96-0 (E)-pyridin-2-aldoxime 
• 3717-28-0 2-chloro benzaldehyde oxime 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 338982-12-0 3-(2-chlorophenyl)-5-isoxazolylcarboxylic acid 
• 543713-32-2 (3-(2-chlorophenyl)isoxazol-5-yl)methanamine 
• 1240190-18-4 (R)-2-butyl-N₄-hydroxy-N₁-[(3-o-chlorophenylisoxazol-5-yl)-methyl]succinamide 
• 1240190-26-4 1-[3-(o-chlorophenyl)isoxazol-5-yl]-3-methylbutan-1-ol 
• 1240190-31-1 N-[1-[3-(o-chlorophenyl)isoxazol-5-yl]-3-methyl]butyl-(2R)-2-tert-butoxycarbonylmethylhexanamide 
• 1240190-34-4 N-[1-[3-(o-chlorophenyl)isoxazol-5-yl]-3-methyl]butyl-(2R)-2-methoxycarbonylmethylhexanamide 
• 1240190-38-8 (2R)-2-butyl-N₄-hydroxy-N₁-[1-[3-(o-chlorophenyl)isoxazol-5-yl]-3-methyl]butylsuccinamide 
• 1240190-28-6 1-[3-(o-chlorophenyl)isoxazol-5-yl]-3-methylbutan-1-amine 
• 1240190-04-8 N-[(3-o-chlorophenylisoxazol-5-yl)-methyl]-(R)-2-tert-butoxycarbonylmethylhexanamide 
• 1240190-12-8 N-[(3-o-chlorophenylisoxazol-5-yl)-methyl]-(R)-2-methoxycarbonylmethylhexanamide 
• 1570098-91-7 ferrocenecarboxylic acid ([3-(2-chlorophenyl)isoxazol-5-yl]methoxy)ester 

Relevant articles and documents

Soluble polymer-supported synthesis of isoxazoles

The first soluble polymer-supported synthesis of isoxazoles through a 1,3-dipolar cycloaddition is described. A soluble polymer-supported alkyne reacts with nitrile oxides generated in situ to give isoxazoles in good yield.

Efficient solvent-free synthesis of bis(indolyl)methanes on SiO2 solid support under microwave irradiation

An efficient synthesis of bis(indolyl)methanes was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85-98 %). Solid support SiO2 was found to possess favorable catalytic and dispersancy parameters for the condensation reaction. Moreover, novel bis(indolyl)methanes containing an isoxazole ring were synthesized via this method in excellent yields (> 94 %) using 3-substituted isoxazole-5-carbaldehydes and indole.

One-pot synthesis of (3-phenylisoxazol-5-yl) methanol derivatives under ultrasound

An ultrasonic-assisted, one-pot, efficient, convenient procedure for the synthesis of (3-phenylisoxazol-5-yl)methanol derivatives has been developed. (3-Phenylisoxazol-5-yl)-methanol derivatives with biological and pharmaceutical property have been synthe