438565-34-5

Basic information

• Product Name: (3-BENZO[1,3]DIOXOL-5-YL-ISOXAZOL-5-YL)-METHANOL
• Synonyms: [3-(1,3-BENZODIOXOL-5-YL)-5-ISOXAZOLYL]METHANOL;(3-BENZO[1,3]DIOXOL-5-YL-ISOXAZOL-5-YL)-METHANOL;[3-(1,3-benzodioxol-5-yl)-1,2-oxazol-5-yl]methanol
• CAS NO: 438565-34-5
• Molecular Formula: C₁₁H₉NO₄
• Molecular Weight: 219.19
• Mol File: 438565-34-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3-BENZO[1,3]DIOXOL-5-YL-ISOXAZOL-5-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (3-BENZO[1,3]DIOXOL-5-YL-ISOXAZOL-5-YL)-METHANOL(438565-34-5)
• EPA Substance Registry System: (3-BENZO[1,3]DIOXOL-5-YL-ISOXAZOL-5-YL)-METHANOL(438565-34-5)

Safety Data

• Hazardous Substances Data: 438565-34-5(Hazardous Substances Data)

Usage

General Description

"(3-benzo[1,3]dioxol-5-yl-isoxazol-5-yl)-methanol" is a chemical compound with the molecular formula C12H9NO3. It is a derivative of both benzo[1,3]dioxole and isoxazole, and contains a methanol group. (3-BENZO[1,3]DIOXOL-5-YL-ISOXAZOL-5-YL)-METHANOL is known for its potential pharmaceutical and biological applications, with reported antioxidant and anti-inflammatory properties. Its structure suggests that it may have utility as a building block for the synthesis of more complex molecules, and its potential pharmacological activities make it a target for further research and development in the field of medicinal chemistry.

Upstream product

• 61946-94-9 N-hydroxy-benzo[1,3]dioxole-5-carboximidoyl chloride 
• 107-19-7 propargyl alcohol 
• 2089-36-3 piperonal oxime 
• 120-57-0 piperonal 
• 2089-36-3 (E)-3,4-methylenedioxybenzaldehyde oxime 
• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 

Downstream Products

• 808739-26-6 3-(benzo[d][1,3]dioxol-5-yl)isoxazole-5-carbaldehyde 
• 1337539-71-5 C₂₇H₃₁FN₄O₃ 
• 885273-58-5 C₁₁H₁₀N₂O₃ 

Relevant articles and documents

Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity

Despite the impressive scientific and technological advances of recent decades, no effective treatment is currently available for Chagas disease. Our research group has been studying the design and synthesis of analogues of natural lignans aiming to identify compounds with antiparasitic activity. This article reports the synthesis of 42 novel bis-heterocyclic derivatives and the structure-activity relationship study conducted based on results of biological assays against Trypanosoma cruzi amastigotes. Thirty-seven compounds were active, and eight of them had GI50 values lower than 100 μM (GI50 88.4–12.2 μM). A qualitative structure activity relationship study using three dimensional descriptors was carried out and showed a correlation between growth inhibitory potency and the presence of bulky hydrophobic groups located at rings A and D of the compounds. Compound 3-(3,4-dimethoxyphenyl)-5-((4-(4-pentylphenyl)-1H-1,2,3-triazol-1-yl)methyl)isoxazole (31) was the most active in the series (GI50 12.2 μM), showing, in vitro, low toxicity and potency similar to benznidazole (GI50 10.2 μM). These results suggest that this compound can be a promising scaffold for the design of new trypanocidal compounds.

Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents

As pyrazole and isoxazole based derivatives are well-known for displaying a considerable biological profile, an attempt has been made to unravel their cytotoxic potential. In this context, a number of pyrazole/isoxazole linked arylcinnamide conjugates (15

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers

A small molecule library of piperazinylalkylisoxazole derivatives containing about 600 compounds was designed, synthesized and evaluated for blocking effects on T-type Ca2+ channel. Several ligands were identified to possess high inhibitory activity against the T-type Ca 2+ channel. The compound 21 with trifluoromethyl substituents at C3-position of phenyl group (R1) and C2- position of phenyl group (R2) showed the highest inhibitory activity with IC50 value of 1.02μM, which is comparable to that of mibefradil.