4393-14-0

Basic information

• Product Name: Benzenemethanamine, N-methylene-
• CAS NO: 4393-14-0
• Molecular Formula: C8H9N
• Molecular Weight: 119.166
• Mol File: 4393-14-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, N-methylene-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, N-methylene-(4393-14-0)
• EPA Substance Registry System: Benzenemethanamine, N-methylene-(4393-14-0)

Safety Data

• Hazardous Substances Data: 4393-14-0(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 100-46-9 benzylamine 
• 1610010-33-7 N-benzyl-4,4-dimethylpent-2-yn-1-amine 
• 2547-66-2 1,3,5-Tribenzyl-1,3,5-triazacyclohexane 
• 67-56-1 methanol 
• 60144-26-5 formaldehyde N,N-tetramethylenehydrazone 
• 27845-50-7 (E)-N-benzylidenebenzylamine 

Downstream Products

• 1419590-27-4 2-benzyl-6-oxa-2-azaspiro[3.4]octan-1-one 
• 1601483-92-4 (E)-methyl 2-(1,3-dibenzylimidazolidin-4-ylidene)acetate 
• 126773-83-9 2-phenyl-5-benzyloxazole 
• 1349129-34-5 1-benzyl-5-methyl-1H-imidazole-4-carbohydrazide 3-oxide 
• 1349129-66-3 1-benzyl-5-methyl-N'-[ (1Z)-1-phenylethylidene]-1H-imidazole-4-carbohydrazide 3-oxide 
• 1349129-64-1 1-benzyl-N'-cyclohexylidene-5-methyl-1H-imidazole-4-carbohydrazide 3-oxide 
• 1349129-57-2 1-benzyl-5-methyl-N'-[ (Z)-phenylmethylidene]-1H-imidazole-4-carbohydrazide 3-oxide 
• 1100817-31-9 C₁₄H₁₆N₂O₃ 
• 1207192-41-3 C₁₇H₂₀NO₂P 

Relevant articles and documents

One-pot Synthesis of a 1,3,7,9-Tetraazacyclododecane Derivative and an Investigation of its Complexation Properties

A one-pot synthesis of a 1,3,7,9-tetraazacyclododecane macrocycle in 37% yield from inexpensive starting materials is described, and its complexation properties with metal cations are investigated.

Development of a Large-Scale Route to an MCH1 Receptor Antagonist: Investigation of a Staudinger Ketene-Imine Cycloaddition in Batch and Flow Mode

A practical large-scale route to an MCH1 receptor antagonist is described. A Staudinger β-lactam synthesis of an imine and an in situ generated ketene was utilized as a key step for the preparation of a spiro-azetidine building block. The reaction was demonstrated in both batch and flow mode and a comparison of these techniques is described.

Method of synthesis of phosphinic acids based on hypophosphites: VIII.1 synthesis of α-aminoalkylphenethylphosphinic acids

Development of methodology of double Arbuzov rearrangement based on hypophosphites allows a one-pot formation of two unsymmetrical phosphorus-carbon bonds by the Michael-Pudovik type reaction of stepwise addition of the intermediately forming silyl esters of trivalent phosphorus to different unsaturated compounds. A procedure was developed of the synthesis of α-aminoalkylphenethylphosphinic acids. Bis-(trimethylsilyl) phenethylphosphonite formed as a result of the addition of bis(trimethylsilyl) hypophosphite to styrene in situ was added without isolation from the reaction mixture to Schiff bases obtained preliminary from benzylamine or diphenylmethylamine and various aldehydes. The subsequent removal of N-protecting groups by hydrogenation or acidic hydrolysis gave a number of new α-aminoalkylphenethylphosphinic acids.