4394-54-1

Basic information

• Product Name: 1-(3-chloro-4-methoxyphenyl)propan-1-one
• Synonyms: 1-(3-chloro-4-methoxyphenyl)propan-1-one
• CAS NO: 4394-54-1
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.64614
• Mol File: 4394-54-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 88–90°C
• Appearance: /
• CAS DataBase Reference: 1-(3-chloro-4-methoxyphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chloro-4-methoxyphenyl)propan-1-one(4394-54-1)
• EPA Substance Registry System: 1-(3-chloro-4-methoxyphenyl)propan-1-one(4394-54-1)

Safety Data

• Hazardous Substances Data: 4394-54-1(Hazardous Substances Data)

Usage

Preparation

Preparation by acylation of 2-chloroanisole,with propionic anhydride in the presence of ferric chloride (62%);with propionyl chloride in the presence of aluminium chloride in carbon disulfide (62%), in methylene chloride for 3 h at 0° or for 1.5 h at r.t. with addition of ammonium chloride (72%).

Upstream product

• 766-51-8 2-Chloroanisole 
• 79-03-8 propionyl chloride 
• 925-90-6 ethylmagnesium bromide 
• 102151-33-7 3-Chloro-4-methoxybenzonitrile 
• 123-62-6 propionic acid anhydride 
• 213470-63-4 (+/-)-1-(3'-chloro-4'-methoxyphenyl)-1-propanol 
• 4903-09-7 3-chloro-4-methoxy-benzaldehyde 
• 37908-96-6 3-chloro-4-methoxy benzoic acid 
• 37908-98-8 methyl 3-chloro-p-anisate 
• 89978-93-8 3-chloro-4-methoxy-benzoic acid amide 
• 36590-49-5 3-chloro-4-methoxybenzoyl chloride 

Downstream Products

• 2892-27-5 3'-chloro-4'-hydroxypropiophenone 
• 102976-53-4 2-Bromo-1-(3-chloro-4-methoxy-phenyl)-propan-1-one 
• 85720-36-1 cis-3,4-bis(3-chloro-4-methoxyphenyl)hex-3-ene 
• 1857-56-3 3-(3-chloro-4-methoxyphenyl)propionic acid 
• 4394-53-0 3-Chlor-4-methoxy-α-hydroxyimino-propiophenon 
• 213470-67-8 1-(3-Chloro-4-methoxy-phenyl)-2-hydroxy-propan-1-one 
• 169217-47-4 (+/-)-(1R,2S)-1-(3'-chloro-4'-methoxyphenyl)-1,2-propanediol 
• 108619-53-0 meso-3,3'-Dichlorhexestrol 
• 94804-95-2 meso-3,4-Bis(3-chlor-4-methoxyphenyl)hexan 
• 13726-29-9 β-(3-Chlor-4-methoxy-phenyl)-propionyl-homoveratrylamin 
• 4394-43-8 α-Amino-3-chlor-4-methoxy-propiophenon 

Relevant articles and documents

Identification and synthesis of novel chlorinated p-anisylpropanoid metabolites from Bjerkandera species

Analysis of the EtOAc extracts from the culture medium of Bjerkandera sp. BOS55 and B. fumosa revealed the presence of two novel chlorinated metabolites. Their structures were unambiguously established as erythro-1- (3',5'-dichloro-4'-methoxyphenyl)-1,2-propanediol (2) and 1-(3'-chloro-4'- methoxyphenyl)-3-hydroxy-1-propanone (3) through synthesis of authentic samples and comparison of retention times and mass spectral data. The production of trametol (1) by Bjerkandera sp, BOS55 was also a new finding.

ACYLATION OF CHLOROANISOLES

In the reaction of 2-, 3-, and 4-chloroanisoles with the chlorides and anhydrides of acetic, propionic, and 4-substituted benzoic acids in the presence of 1E-3 mole of ferric chloride 35-80percent of the ketone fraction was obtained.Under the reaction con