440094-14-4

Basic information

• Product Name: 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXALDEHYDE
• Synonyms: 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXALDEHYDE;6-Chloro-imidazo[1,2-b]pyridazine-2-carbaldehyde
• CAS NO: 440094-14-4
• Molecular Formula: C7H4 Cl N3 O
• Molecular Weight: 181.58
• Mol File: 440094-14-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXALDEHYDE(440094-14-4)
• EPA Substance Registry System: 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXALDEHYDE(440094-14-4)

Safety Data

• Hazardous Substances Data: 440094-14-4(Hazardous Substances Data)

Usage

General Description

6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXALDEHYDE is a chemical compound with the molecular formula C8H5ClN4O. It is an aldehyde derivative that contains a chloro-substituted imidazo[1,2-b]pyridazine ring structure. 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXALDEHYDE may have applications in pharmaceutical research, specifically in the development of new drugs or pharmaceutical intermediates. Its unique structure and chemical properties make it a potential candidate for further study in the fields of medicinal chemistry and drug discovery.

Upstream product

• 79-46-9 2-nitropropane 
• 154578-23-1 6-chloro-2-(chloromethyl)imidazo[1,2-b]pyridazine 
• 64067-99-8 ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate 
• 572910-59-9 methyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate 

Relevant articles and documents

COMPOUNDS

The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.

Synthesis of 2-substituted-3-nitroimidazo[1,2-b]pyridazines as potential biologically active agents

A new heterocyclic reductive alkylating agent, 6-chloro-2-chloromethyl-3-nitroimidazo[1,2-b]pyridazine, was synthesized for the first time. It was shown to react under phase-transfer catalysis conditions with 2-nitropropane anion by an SRN1 mechanism to give excellent yield of isopropylidene derivative formed from a base-promoted nitrous acid elimination of C-alkylation product. Extension of this SRN1 reaction to various nitronate anions led to a new class of 3-nitroimidazo[1,2-b]pyridazine derivatives bearing a trisubstituted double bond at the 2-position.