440125-24-6

Basic information

• Product Name: Carbamic acid, (1-formylpentyl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, (1-formylpentyl)-, 1,1-dimethylethyl ester (9CI);tert-butyl 1-oxohexan-2-ylcarbamate
• CAS NO: 440125-24-6
• Molecular Formula: C11H21NO3
• Molecular Weight: 215.28934
• Product Categories: N-BOC
• Mol File: 440125-24-6.mol
• Article Data: 36

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, (1-formylpentyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (1-formylpentyl)-, 1,1-dimethylethyl ester (9CI)(440125-24-6)
• EPA Substance Registry System: Carbamic acid, (1-formylpentyl)-, 1,1-dimethylethyl ester (9CI)(440125-24-6)

Safety Data

• Hazardous Substances Data: 440125-24-6(Hazardous Substances Data)

Upstream product

• 87974-77-4 methyl (2S)-2-tert-butoxycarbonylaminohexanoate 
• 116640-17-6 tert-butyl [(1S)-1-(hydroxymethyl)pentyl]carbamate 
• 104062-69-3 N-Methoxy-N-methyl 2(S)-(tert-butoxycarbonylamino) hexanamide 
• 335628-07-4 (4S,5R)-5-benzyloxy-3-tert-butoxycarbonyl-4-butyl-2-oxazolidinone 
• 6404-28-0 Boc-Nle-OH 
• 327-57-1 L-Norleucine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 335627-55-9 (4S,5R)-5-benzyloxy-4-butyl-2-oxazolidinone 
• 80696-29-3 (S)-(+)-2-Amino-1-hexanol 
• 254438-02-3 [1-(methoxy-methyl-carbamoyl)-pentyl]-carbamic acid tert-butyl ester 
• 125342-48-5 2(S)-(tert-Butoxycarbonylamino)hexanoic acid 
• 116640-17-6 tert-butyl (R)-(1-hydroxyhexan-2-yl)carbamate 
• 55674-63-0 (R)-2-(N-t-butoxycarbonylamino)hexanoic acid 
• 169448-54-8 (R)-N-(tert-butoxycarbonyl)-2-amino-3-propyl-N-methoxy-N-methylpropionamide 

Relevant articles and documents

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MG11 is a truncated analog of minigastrin, a peptide with high affinity and specificity toward the cholecystokinin-2 receptor (CCK2R), which is overexpressed by different tumors. Thus, radiolabeled MG11 derivatives have great potential for use in cancer d

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

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Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase

The malarial PfA-M1 metallo-aminopeptidase is considered a putative drug target. The natural product dipeptide mimetic, bestatin, is a potent inhibitor of PfA-M1. Herein we present a new, efficient, and high-yielding protocol for the synthesis of bestatin derivatives from natural and unnatural N-Boc-d-amino acids. A diverse library of bestatin derivatives was synthesized with variants at the side chain of either the α-hydroxyβ-amino acid (P1) or the adjacent naturalα-amino acid (P1′). Surprisingly, we found that extended aromatic side chains at the P1 position resulted in potent inhibition against PfA-M1. To understand these data, we determined the X-ray cocrystal structures of PfA-M1 with two derivatives having either a Tyr(OMe) 15 or Tyr(OBzl) 16 at the P1 position and observed substantial inhibitor-induced rearrangement of the primary loop within the PfA-M1 pocket that interacts with the P1 side chain. Our data provide important insights for the rational design of more potent and selective inhibitors of this enzyme that may eventually lead to new therapies for malaria.