440667-51-6Relevant articles and documents
Studies on pyrrolidinones: Some attempts to improve the synthesis of methyl N-(3,4,4′,5-tetramethoxybenzhydryl)pyroglutamate (HEI 81) by using N-acyl iminium salts methodologies
Bourry, Anne,Pitard, Franck,Rigo, Benoit,Sanz, Gerard,Camus, Fabrice,Norberg, Bernadette,Durant, Francois,Couturier, Daniel
, p. 109 - 118 (2007/10/03)
Some ways to use the N-acyl iminium salt methodologies to synthesize a new inhibitor of tubulin polymerization, methyl N-(3,4,4′,5-tetramethoxybenzhydryl)pyroglutamate (HEI 81) were studied. The most interesting reactions utilize a new pyroglutamic lactone (3-(3,4,5-trimethoxyphenyl)dihydropyrrolo[1,2-c]oxazole-1,5-dione).