441055-34-1Relevant articles and documents
Heterobiaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part II
Trova, Michael P.,Barnes, Keith D.,Alicea, Luis,Benanti, Travis,Bielaska, Mark,Bilotta, Joseph,Bliss, Brian,Duong, Thuy Nguyen,Haydar, Simon,Herr, R. Jason,Hui, Yu,Johnson, Matthew,Lehman, John M.,Peace, Denise,Rainka, Matthew,Snider, Patricia,Salamone, Susan,Tregay, Steven,Zheng, Xiaozhang,Friedrich, Thomas D.
scheme or table, p. 6613 - 6617 (2010/06/12)
C-6 Biarylmethylamino purine derivatives of roscovitine (1) inhibit cyclin dependent kinases and demonstrate potent antiproliferative activity. Replacement of the aryl rings of the C-6 biarylmethylamino group with heterobiaryl rings has provided compounds