441060-95-3

Basic information

• Product Name: 2-(2-CHLORO-4-METHOXYPHENYL)-3-OXOBUTYRONITRILE
• Synonyms: 2-(2-CHLORO-4-METHOXYPHENYL)-3-OXOBUTYRONITRILE
• CAS NO: 441060-95-3
• Molecular Formula: C₁₁H₁₀ClNO₂
• Molecular Weight: 223.66
• Mol File: 441060-95-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 84-86°C
• Boiling Point: 316.133°C at 760 mmHg
• Flash Point: 144.992°C
• Appearance: /
• Density: 1.226g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(2-CHLORO-4-METHOXYPHENYL)-3-OXOBUTYRONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-CHLORO-4-METHOXYPHENYL)-3-OXOBUTYRONITRILE(441060-95-3)
• EPA Substance Registry System: 2-(2-CHLORO-4-METHOXYPHENYL)-3-OXOBUTYRONITRILE(441060-95-3)

Safety Data

• Hazard Codes: Xi
• RIDADR: UN3439
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 441060-95-3(Hazardous Substances Data)

Usage

General Description

2-(2-Chloro-4-methoxyphenyl)-3-oxobutyronitrile, also known as clofencet or clophencet, is a chemical compound used in the synthesis of pharmaceuticals. It is an oxo-containing nitrile compound with a chloro and methoxy substituent on the phenyl ring. Clofencet has been studied for its potential anti-inflammatory and analgesic properties, making it a potential candidate for the development of new medications. Additionally, its nitrile group can potentially be used in the synthesis of other complex organic molecules. However, like with any chemical compound, proper handling and safety precautions should be observed when working with clofencet.

InChI:InChI=1/C11H10ClNO2/c1-7(14)10(6-13)9-4-3-8(15-2)5-11(9)12/h3-5,10H,1-2H3

Upstream product

• 141-78-6 ethyl acetate 
• 170737-93-6 2-chloro-4-methoxyphenylacetonitrile 
• 50638-46-5 4-bromo-3-chloroanisole 
• 70807-22-6 3-hydroxycrotononitrile sodium salt 

Downstream Products

• 817636-89-8 4-(2-chloro-4-methoxyphenyl)-5-methyl-2H-pyrazol-3-ylamine 
• 817636-89-8 4-(2-chloro-4-methoxy-phenyl)-5-methyl-1H-pyrazol-3-ylamine 
• 1338727-93-7 3-(2-chloro-4-methoxyphenyl)-2-methyl-6,7-dihydrofuro[2,3-d]pyrazolo[1,5-a]pyrimidin-8-amine 
• 1338728-00-9 3-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-2-methyl-6,7-dihydrofuro[2,3-d]pyrazolo[1,5-a]pyrimidin-8-amine 
• 857262-72-7 3-chloro-4-[8-(1-ethylpropylamino)-2-methyl-6,7-dihydro-5H-1,4,8a-triaza-s-indacen-3-yl]-phenol 
• 1338727-99-3 3-[2-chloro-4-(difluoromethoxy)phenyl]-N-(1-ethylpropyl)-2-methyl-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidin-8-amine 
• 817636-90-1 8-hydroxy-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidine 
• 817636-91-2 8-chloro-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidine 
• 441060-02-2 (1-ethyl-propyl)-[3-(4-methoxy-2-chlorophenyl)-2-methyl-6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl]-amine 
• 1338727-94-8 5-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6-methyl-2,3-dihydrofuro[3,2-d]pyrazolo[1,5-a]pyrimidin-9-amine 
• 1100592-51-5 3-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-2,5,6-trimethylpyrazolo[1,5-a]pyrimidin-7-amine 
• 817636-93-4 8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidine tosylate 

Relevant articles and documents

6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists

To identify an orally active corticotropin-releasing factor 1 receptor antagonist, a series of 6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives were designed, synthesized and evaluated. An in vitro study followed by in vivo and pharmacokinetic studies of these heterotricyclic compounds led us to the discovery of an orally active CRF1 receptor antagonist. The results of a structure-activity relationship study are presented.

TRICYCLIC AND HETEROCYCLIC DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT

Tri- heterocyclic compound of formula (I) wherein each of W, X and Y is carbon or nitrogen; each of U and Z is CR2, NR13, nitrogen, oxygen, sulfur etc.; A ring is carbocyclic ring, heterocyclic ring; R1 is alkyl, alkenyl,