441064-74-0

Basic information

• Product Name: Pyrido[3,4-d]pyrimidine, 5,6,7,8-tetrahydro-4-(4-morpholinyl)-7-(phenylmethyl)-
• CAS NO: 441064-74-0
• Molecular Formula: C18H22N4O
• Molecular Weight: 310.399
• Mol File: 441064-74-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyrido[3,4-d]pyrimidine, 5,6,7,8-tetrahydro-4-(4-morpholinyl)-7-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[3,4-d]pyrimidine, 5,6,7,8-tetrahydro-4-(4-morpholinyl)-7-(phenylmethyl)-(441064-74-0)
• EPA Substance Registry System: Pyrido[3,4-d]pyrimidine, 5,6,7,8-tetrahydro-4-(4-morpholinyl)-7-(phenylmethyl)-(441064-74-0)

Safety Data

• Hazardous Substances Data: 441064-74-0(Hazardous Substances Data)

Upstream product

• 69981-00-6 7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one 
• 110-91-8 morpholine 
• 192869-80-0 7-Benzyl-4-chloro-5,6,7,8-tetrahydro-1,3,7-triazanaphthalene 

Relevant articles and documents

Process development and scale-up of a selective α1- adrenoceptor antagonist

A synthetic route to a potent and selective α-1-adrenergic receptor antagonist has been developed and demonstrated in a pilot plant. The route has been used in two pilot plant campaigns and has produced RO3203546 in 2.3 and 12.0 kg batch sizes. The first pilot plant campaign focused primarily on the end-game of the process with particular emphasis on the development of a method to isolate the active pharmaceutical ingredient (API). The second pilot plant campaign allowed front-end process improvements to be demonstrated. The reiterative process improvements resulted in an economical process with improved throughput and product quality when compared to the original discovery synthesis.