4411-97-6

Basic information

• Product Name: 2-Butenoic acid, 2,3-dimethyl-
• Synonyms: 2-Butenoic acid, 2,3-dimethyl-;trimethyl acrylic acid;2,3-Dimethyl-crotonsaeure;2,3-dimethyl-crotonic acid;2,3-Dimethyl-2-butenoic acid;2-Butenoic acid,2,3-dimethyl
• CAS NO: 4411-97-6
• Molecular Formula: C6H10O2
• Molecular Weight: 114.144
• Mol File: 4411-97-6.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 2,3-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 2,3-dimethyl-(4411-97-6)
• EPA Substance Registry System: 2-Butenoic acid, 2,3-dimethyl-(4411-97-6)

Safety Data

• Hazardous Substances Data: 4411-97-6(Hazardous Substances Data)

Upstream product

• 30168-03-7 2,3,3-trimethyl-glutaric acid 
• 34849-39-3 ethyl 3-hydroxy-2,3-dimethylbutanoate 
• 71-43-2 benzene 
• 18456-85-4 4,5,5-trimethyl-cyclohexane-1,3-dione 
• 3017-70-7 2-bromo-3-methylbut-2-ene 
• 124-38-9 carbon dioxide 
• 78-79-5 isoprene 
• 684-02-6 4-chloro-3,4-dimethyl-2-pentanone 
• 594-51-4 2,3-dibromo-2-methylbutane 
• 36598-04-6 2,3-dimethyl-3-butenoic acid 
• 78775-79-8 bromo-tert-butyl-malonic acid 
• 23985-53-7 (R,S)-hydroxy-2,3-dimethylbutansaeure 
• 7664-93-9 sulfuric acid 
• 684-94-6 3,4-dimethyl-3-pentene-2-one 

Downstream Products

• 14287-61-7 2,3-dimethylbutyric acid 
• 24735-54-4 2,3-Dimethyl-2-butensaeureanilid 
• 91970-08-0 2,3-dimethyl-3-p-tolyl-butyric acid 
• 15071-34-8 (2S)-2,3-Dimethylbutanoic acid 
• 104848-77-3 4-methylene-5,5-dimethyl-1,2-dioxolan-3-one 
• 1121-05-7 2,3-dimethylcyclopent-2-enone 
• 1276669-59-0 N-(3,5-dimethoxyphenyl)-2,3-dimethylbut-2-enamide 
• 1276669-72-7 2,3-dimethyl-N-(3,5-dimethylphenyl)but-2-enamide 
• 14287-61-7 (2R)-2,3-Dimethylbutanoic acid 

Relevant articles and documents

Efficient one-to-one coupling of easily available 1,3-dienes with carbon dioxide

An efficient one-to-one coupling reaction of atmospheric pressure carbon dioxide with 1,3-dienes is realized for the first time through PSiP-pincer type palladium-catalyzed hydrocarboxylation. The reaction is applicable to various 1,3-dienes including easily available chemical feedstock such as 1,3-butadiene and isoprene. This protocol affords a highly useful method for the synthesis of β,γ-unsaturated carboxylic acid derivatives from CO2.

Enantioselective Friedel-Crafts reactions of ethenetricarboxylates and substituted pyrroles and furans and intramolecular reaction of benzene derivatives

Compared to enantioselective Friedel-Crafts reactions of indoles, reactions of alkylidene malonates with monocyclic aromatic compounds generally proceed with low enantioselectivity. The Friedel-Crafts reactions of ethenetricarboxylates 1 and monocyclic heteroaromatic compounds, such as substituted pyrroles and furans were investigated. The reaction of 1 with 2,4-dimethylpyrrole in the presence of a chiral bisoxazoline-copper(II) complex (10 mol %) in tetrahydrofuran at room temperature gave alkylated products in up to 72% ee. The reaction of 1 with 2-substituted furans gave alkylated products in 46-62% ee. The absolute stereochemistry of the furan Friedel-Crafts product 7e was determined by transformation to the known 2,3-dimethylbutyric acid. The intramolecular reaction of benzene derivatives gave cyclized products up to 56% ee.

Pyrrolidine modulators of chemokine receptor activity

The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6, R14and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.