441715-26-0

Basic information

• Product Name: 6-FLUORO-1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID
• Synonyms: 6-FLUORO-1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID;1H-Indole-3-carboxylic acid, 6-fluoro-1-methyl-
• CAS NO: 441715-26-0
• Molecular Weight: 193.177
• Mol File: 441715-26-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 392.0±22.0 °C(Predicted)
• Density: 1.34±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 6-FLUORO-1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID(441715-26-0)
• EPA Substance Registry System: 6-FLUORO-1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID(441715-26-0)

Safety Data

• Hazardous Substances Data: 441715-26-0(Hazardous Substances Data)

Upstream product

• 441715-92-0 6-fluoro-1-methyl-1H-indole 
• 399-51-9 6-fluoro-1H-indole 
• 1492020-32-2 C₁₁H₇F₄NO 
• 441715-93-1 6-fluoro-1-methyl-1H-indole-3-carbaldehyde 

Relevant articles and documents

Salicylaldehyde-Promoted Cobalt-Catalyzed C-H/N-H Annulation of Indolyl Amides with Alkynes: Direct Synthesis of a 5-HT3 Receptor Antagonist Analogue

A cobalt-catalyzed annulation of the C(sp2)-H/N-H bond of indoloamides with alkynes assisted by 8-aminoquinoline is reported for the synthesis of six-membered indololactams. The use of salicylaldehyde as the ligand is crucial for this transformation. The protocol has a broad scope for both alkynes and indoles. Preparing an active Co complex illustrates that salicylaldehyde plays a key role in the C-H activation step. The synthetic applications are proven by the gram-scale reaction and one-step construction of the multicyclic 5-HT3 receptor antagonist.

VLA-4 INHIBITORS

The present invention relates to a compound represented by the following formula (I): (wherein, W represents WA-A1 -WB - (in which, WA is substituted or unsubstituted aryl, etc., A1 is -NR1-, single bond, -C(O)-, etc., and WB is substituted or unsubstituted arylene, etc.), R is single bond, -NH-, -OCH2-, alkenylene, etc., X is -C(O) -CH2-, etc., and M is, for example, the following formula: (in which, R11, R12 and R13 each independently represents hydrogen, hydroxyl, amino, halogen, etc., R14 is hydrogen or lower alkyl, Y represents -CH2-O-, etc., Z is substituted or unsubstituted arylene, etc., A2 is single bond, etc, and R10 is hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VAL-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like.