441717-40-4

Basic information

• Product Name: (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester
• Synonyms: (R)-1-Boc-pyrrolidine-1,3-dicarboxylate;(R)-1-BOC-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER;(R)-1-tert-Butoxycarbonyl-pyrrolidine-3-carboxylic acid methyl ester;(R)-Methyl 1-Boc-pyrrolid...;(R)-1-BOC-Pyrrolidine-3-carboxylic acid ethyl ester;(R)-Methyl 1-Boc-pyrrolidine-3-carboxylate;1-tert-butyl 3-Methyl (3R)-pyrrolidine-1,3-dicarboxylate;O1-tert-Butyl O3-methyl (3R)-pyrrolidine-1,3-dicarboxylate
• CAS NO: 441717-40-4
• Molecular Formula: C11H19NO4
• Molecular Weight: 229.27
• EINECS: 1308068-626-2
• Product Categories: Pyrrole&Pyrrolidine&Pyrroline
• Mol File: 441717-40-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 374.4°C at 760 mmHg
• Flash Point: 180.3°C
• Appearance: /
• Density: 1.301g/cm³
• Vapor Pressure: 1.23E-06mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester(441717-40-4)
• EPA Substance Registry System: (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester(441717-40-4)

Safety Data

• Hazardous Substances Data: 441717-40-4(Hazardous Substances Data)

Usage

General Description

"(R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester" is a chemical compound with the molecular formula C12H21NO4. It is a derivative of pyrrolidine, a five-membered nitrogen-containing heterocycle. (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester is used in organic synthesis as a chiral building block, as the Boc (tert-butoxycarbonyl) protecting group allows for selective reactions and the resulting enantiomerically pure products. The methyl ester group also makes it a versatile intermediate for the preparation of other organic compounds. Overall, "(R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester" is a valuable compound for the synthesis of complex organic molecules, particularly in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C11H17NO6/c1-11(2,3)18-10(16)17-9(15)12-5-4-7(6-12)8(13)14/h7H,4-6H2,1-3H3,(H,13,14)/t7-/m1/s1

Upstream product

• 72925-16-7 (R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 72925-16-7 1-boc-pyrrolidine-3-carboxylic acid 
• 192214-06-5 (R)-1-((benzyloxy)-carbonyl)pyrrolidine-3-carboxylic acid 
• 1217655-90-7 (R)-methyl-1-benzyloxycarbonyl-pyrrolidine-3-carboxylate 
• 99735-47-4 (3R)-1-[(R)-1-phenylethyl]-3-(hydroxymethyl)pyrrolidine 
• 192214-05-4 benzyl (R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 198959-37-4 (R)-methyl pyrrolidine-3-carboxylate hydrochloric acid 

Downstream Products

• 1436862-03-1 trans-3-[N'-(6-benzyloxy-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carbonyl)-hydrazinocarbonyl]-(R)-pyrrolidin-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

A PROCESS FOR PREPARATION OF (2S, 5R)-7-OXO-6-SULPHOOXY-2-[((3R)-PYRROLIDINE-3-CARBONYL)-HYDRAZINO CARBONYL]-1,6-DIAZA-BICYCLO[3.2.1]OCTANE

A process for preparation of (2S, 5R)-7-oxo-6-sulphooxy-2- [((3R)-pyrrolidine-3-carbonyl)-hydrazino carbonyl]-1,6-diaza- bicyclo[3.2.1]octane is disclosed comprising reacting a compound of Formula (II) with a compound of Formula (III) to obtain a compound

Enzymatic resolution of n-substituted-β-prolines

A general and straightforward strategy for enzymatic resolution of N-substituted-β-proline has been successfully designed and developed in our research laboratories. A first affinity screen is followed by ratio enzyme/substrate optimization to source our

PYRROLIDINE DERIVATIVES AS ERK INHIBITORS

Disclosed are the ERK inhibitors of Formula (1.0): and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of Formula (1.0).