442157-13-3

Basic information

• Product Name: Benzenepropanoic acid, a-diazo-b-hydroxy-3-(trifluoromethyl)-, ethyl ester
• CAS NO: 442157-13-3
• Molecular Formula: C12H11F3N2O3
• Molecular Weight: 288.226
• Mol File: 442157-13-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-diazo-b-hydroxy-3-(trifluoromethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-diazo-b-hydroxy-3-(trifluoromethyl)-, ethyl ester(442157-13-3)
• EPA Substance Registry System: Benzenepropanoic acid, a-diazo-b-hydroxy-3-(trifluoromethyl)-, ethyl ester(442157-13-3)

Safety Data

• Hazardous Substances Data: 442157-13-3(Hazardous Substances Data)

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 454-89-7 3-Trifluoromethylbenzaldehyde 

Downstream Products

• 1717-42-6 ethyl (3-trifluoromethylbenzoyl)acetate 

Relevant articles and documents

DBU-catalyzed condensation of acyldiazomethanes to aldehydes in water and a new approach to ethyl β-hydroxy α-arylacrylates

DBU-catalyzed condensation of ethyl diazoacetate (EDA) with aldehydes in pure water afforded corresponding β-hydroxy α-diazo carbonyl compounds. The β-hydroxy group of the products was further converted into β-siloxy group. The Rh(II)-catalyzed reaction of the β-aryl β-siloxy α-diazo carbonyl compounds gave 1,2-aryl shift products predominantly. The three-step transformation constitutes an efficient synthesis of ethyl β-hydroxy α-arylacrylates.