4426-47-5

Basic information

• Product Name: 1-Butaneboronic acid
• Synonyms: 1-(dihydroxyboryl)butane;1-BUTANEBORONIC ACID;1-BUTYLBORONIC ACID;BUTYLBORIC ACID;BUTYLBORONIC ACID;N-BUTYLBORONIC ACID;NBBA;N-BUTANEBORONIC ACID
• CAS NO: 4426-47-5
• Molecular Formula: C₄H₁₁BO₂
• Molecular Weight: 101.94
• EINECS: 224-607-7
• Product Categories: blocks;BoronicAcids;Boronic Acid;Boronic Acid, etc. (GC Derivatizing Reagents);Analytical Chemistry;B (Classes of Boron Compounds);Boronic Acids;GC Derivatizing Reagents;CHIRAL CHEMICALS
• Mol File: 4426-47-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 90-92 °C(lit.)
• Boiling Point: 189.2 °C at 760 mmHg
• Flash Point: 68.2 °C
• Appearance: Clear colorless to slightly yellow/Liquid
• Density: 0.914 g/cm³
• Vapor Pressure: 0.158mmHg at 25°C
• Refractive Index: 1.4
• Storage Temp.: 0-6°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 10.37±0.43(Predicted)
• Water Solubility: ca 2.5 g/100 mL
• Sensitive: Air Sensitive & Hygroscopic
• BRN: 1733489
• CAS DataBase Reference: 1-Butaneboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butaneboronic acid(4426-47-5)
• EPA Substance Registry System: 1-Butaneboronic acid(4426-47-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 22-24/25-37/39-26-36
• WGK Germany: 3
• F: 3-10-23
• TSCA: No
• HazardClass: IRRITANT
• Hazardous Substances Data: 4426-47-5(Hazardous Substances Data)

Usage

Chemical Properties

white to faintly beige shinying platelets

Uses

Different sources of media describe the Uses of 4426-47-5 differently. You can refer to the following data:
1. n-Butylboronic acid can be used in suzuki reaction.
2. n-Butylboronic acid is a boronic acid derivative that can be used as a transport carriers in membrane-based sugar separations. n-Butylboronic acid is used as an analytical reagent in the determination of serum glucose.
3. 1-Butylboronic acid is used as a reagent for preparation of volatile derivatives of diols, e.g. carbohydrates, for GC and mass spectrometry and to prepare chiral oxazaborolidines. It is a precursor to unsymmetric borinic acids, which are inhibitors of serine proteases. Can be used as a transport carrier in membrane-based sugar separations and as an analytical reagent in the determination of serum glucose.

Purification Methods

Butylboronic acid (1-butanedihydroxyborane) [4426-47-5] M 101.9, m 90 -92o, 94 -96o, pKEst ~8.8.acuo. [Corey et al. J Am Chem Soc 116 3151 1994, Quallich et al. J Am Chem Soc 116 8515 1994, Seerden Tetrahedron Lett 35 4419 1994, Beilstein 4 IV 4383.]

InChI:InChI=1/C4H11BO2/c1-2-3-4-5(6)7/h6-7H,2-4H2,1H3

Upstream product

• 109-72-8 n-butyllithium 
• 688-74-4 boric acid tributyl ester 
• 693-03-8 n-butyl magnesium bromide 
• 68498-84-0 methyl boric acid 
• 542-69-8 1-iodo-butane 
• 124-38-9 carbon dioxide 
• 89598-97-0 (5-bromo-2-hydroxyphenyl)boronic acid 
• 32999-10-3 2-butyl-1,3,2-benzodioxaborole 
• 109-65-9 1-bromo-butane 
• 86595-32-6 n-butyldiisopropoxyborane 
• 121-43-7 Trimethyl borate 
• 7359-98-0 tri-n-butylboroxine 
• 7732-18-5 water 
• 4887-12-1 1,2-di-n-butyl-1,2-bis(dimethylamino) diborane 

Downstream Products

• 92527-13-4 2-butyl-1,3,6,2-dioxazaborocane 
• 52572-01-7 α-D-Xylofuranose 1,2 : 3,5-bis(butanboronat) 
• 18885-79-5 2-butyl-4-phenyl-[1,3,2]dioxaborolane 
• 53829-55-3 α-L-Furopyranose 1,2 : 3,4-bis(butanboronat) 
• 18885-81-9 Butylboronsaeure-o-benzylenester 
• 19458-28-7 2-butyl-(3ar,8ac)-8,8a-dihydro-3aH-indeno[1,2-d][1,3,2]dioxaborole 
• 32999-10-3 2-butyl-1,3,2-benzodioxaborole 
• 30169-71-2 2-n-butyl-1,3,2-dioxaborinane 
• 97594-57-5 C₁₆H₁₉BO₂ 
• 158264-26-7 Methyl 4-butylphenylacetate 
• 111-65-9 octane 
• 71-36-3 butan-1-ol 
• 129145-37-5 (S)-tetrahydro-1-butyl-3,3-diphenyl-1H,3H-pyrrolo{2,1-c}{1,3,2}oxazaborole 
• 4394-76-7 6-methyl-2H-pyran-2-one 

Relevant articles and documents

COMPOUNDS AND SYNTHETIC METHODS FOR THE PREPARATION OF RETINOID X RECEPTOR-SPECIFIC RETINOIDS

Provided herein are compounds useful for the preparation of compounds that have retinoid-like biological activity. Also provided herein are processes for the preparation of compounds that have retinoid-like biological activity.

Amino acid-promoted C-H alkylation with alkylboronic acids using a removable directing group

Palladium-catalyzed C-H alkylation reaction with alkylboronic acids has successfully been developed using a removable pyridyldiisopropylsilyl directing group. The amino acid played a crucial role as a ligand in the reaction. The alkylation protocol is also applicable to the coupling of C(sp3)-H bonds with alkylboronic acids.

GRF analogs with increased biological potency

The present invention relates to chimeric fatty body-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-GRF analogs include an hydrophobic moiety (tail), and can be prepared, either by anchoring at least one hydrophobic tail to the GRF, in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.