4428-13-1

Basic information

• Product Name: 1,1,2-triphenylethanol
• Synonyms: 1,1,2-triphenylethanol;α,α-Diphenylbenzeneethanol
• CAS NO: 4428-13-1
• Molecular Formula: C₂₀H₁₈O
• Molecular Weight: 274.35632
• EINECS: 224-614-5
• Mol File: 4428-13-1.mol
• Article Data: 37

Chemical Properties

• Melting Point: 89.5°C
• Boiling Point: 377.34°C (rough estimate)
• Flash Point: 153.1 °C
• Appearance: /
• Density: 1.0338 (rough estimate)
• Vapor Pressure: 4.81E-07mmHg at 25°C
• Refractive Index: 1.4880 (estimate)
• CAS DataBase Reference: 1,1,2-triphenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,2-triphenylethanol(4428-13-1)
• EPA Substance Registry System: 1,1,2-triphenylethanol(4428-13-1)

Safety Data

• Hazardous Substances Data: 4428-13-1(Hazardous Substances Data)

Usage

General Description

1,1,2-triphenylethanol, also known as "TPE," is a white crystalline solid that belongs to the class of organic compounds known as triphenylethanols. It is a synthetic compound that is widely used in the field of organic chemistry as a chiral auxiliary in asymmetric synthesis reactions and as a versatile building block for the construction of various biologically active molecules. TPE has also been studied for its potential antioxidant and antibacterial properties, making it a promising candidate for applications in the pharmaceutical and cosmetic industries. Additionally, TPE is known for its role as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to its significance in the field of chemical research and development.

InChI:InChI=1/C20H18O/c21-20(18-12-6-2-7-13-18,19-14-8-3-9-15-19)16-17-10-4-1-5-11-17/h1-15,21H,16H2

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 119-61-9 benzophenone 
• 1589-82-8 phenylmagnesium bromide 
• 2785-29-7 benzyl potassium 
• 882-59-7 1,1-diphenyloxirane 
• 591-51-5 phenyllithium 
• 4479-98-5 2,2,3-triphenyloxirane 
• 7716-70-3 acetic acid-(1,1,2-triphenyl-ethyl ester) 
• 101-97-3 Ethyl 2-phenylethanoate 
• 108-88-3 toluene 
• 6921-34-2 benzylmagnesium chloride 
• 100-44-7 benzyl chloride 
• 591-50-4 iodobenzene 
• 770-09-2 benzyltrimethylsilane 

Downstream Products

• 58-72-0 Triphenylethylene 
• 34131-92-5 nitro-tris-(4-nitro-phenyl)-ethene 
• 5670-70-2 nitro-triphenyl-ethene 
• 29240-44-6 2-bromo-1,1,2-triphenyl-ethanol 
• 55682-86-5 1,1,2-tricyclohexyl-ethane 
• 6973-87-1 1-chloro-1,1,2-triphenyl-ethane 
• 1520-42-9 1,1,2-triphenylethane 
• 119-61-9 benzophenone 
• 100-52-7 benzaldehyde 
• 65-85-0 benzoic acid 
• 18084-97-4 chlorotriphenylethylene 
• 16876-18-9 1,2,2-triphenylpropane 
• 109686-85-3 1,2-dichlorotriphenylethane 
• 74064-34-9 1,2-dibromo-1,1,2-triphenyl-ethane 

Relevant articles and documents

Notable temperature effect on the stereoselectivity in the photochemical [2+2] cycloaddition reaction (Paternò-Büchi reaction) of 2,3-dihydrofuran-3-ol derivatives with benzophenone

A notable temperature effect (nonlinear Eyring plot) on stereoselectivity, trans-configured oxetane 2 versus cis-configured oxetane 2, is reported in the photochemical [2+2] cycloaddition reaction (Paternò-Büchi reaction) of 2,3-dihydrofuran-3-ol derivatives 1 with benzophenone.

Iron-catalysed 1,2-aryl migration of tertiary azides

1,2-Aryl migration of α,α-diaryl tertiary azides was achieved by using the catalytic system of FeCl2/N-heterocyclic carbene (NHC) SIPr·HCl. The reaction generated aniline products in good yields after one-pot reduction of the migration-resultant imines.

Iron-Catalyzed Nucleophilic Addition Reaction of Organic Carbanion Equivalents via Hydrazones

Earth-abundant and well-defined iron complexes are found to be cheap and effective catalysts for a series of "umpolung" nucleophilic additions of hydrazones. The new catalytic system not only maintains the broad substrate scope of an earlier expensive ruthenium system but also attains chemoselectivity of different kinds of carbonyl groups. Furthermore, the iron catalyst enables this reaction at ambient temperature.

Benzyllithiums bearing aldehyde carbonyl groups. A flash chemistry approach

Reductive lithiation of benzyl halides bearing aldehyde carbonyl groups followed by reaction with subsequently added electrophiles was successfully accomplished without affecting the carbonyl groups by taking advantage of short residence times in flow microreactors.