4430-35-7

Basic information

• Product Name: 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE
• Synonyms: 6-METHYLSULFINYLHEXYL ISOTHIOCYANATE;1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE;6-HITC;6-MITC
• CAS NO: 4430-35-7
• Molecular Formula: C8H15NOS2
• Molecular Weight: 205.34
• Product Categories: Aliphatics, Sulfur & Selenium Compounds
• Mol File: 4430-35-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 385.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.12±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• CAS DataBase Reference: 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE(4430-35-7)
• EPA Substance Registry System: 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE(4430-35-7)

Safety Data

• Hazardous Substances Data: 4430-35-7(Hazardous Substances Data)

Usage

Description

1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE, also known as 6-Methylsulfinylhexyl isothiocyanate (6-MSITC), is an isothiocyanate compound derived from Wasabia japonica (wasabi). It exhibits a range of biological activities, including the inhibition of nitric oxide production, aggregation of human platelets, and cell survival in various cancer cell lines. Additionally, it has demonstrated neuroprotective effects in a mouse model of Parkinson's disease and anti-metastatic properties in a murine melanoma model.

Uses

Used in Pharmaceutical Industry:
1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE is used as a potential therapeutic agent for various reasons, including its ability to inhibit glycogen synthase kinase-3β, reduce cell survival in multiple cancer cell lines, and exhibit neuroprotective effects in Parkinson's disease models.
Used in Cancer Research:
In cancer research, 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE is used as an inhibitor of various cancer cell lines, including breast, brain, colon, lung, ovarian, renal, and prostate cancers, due to its ability to reduce cell survival with a mean IC50 of 43.7 μM.
Used in Neurodegenerative Disease Research:
1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE is used as a neuroprotective agent in the context of Parkinson's disease, as it has been shown to reduce apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model induced by 6-OHDA.
Used in Anti-metastatic Applications:
In anti-metastatic research, 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE is used to reduce the number of lung metastases in a B16/F10 murine melanoma model, showcasing its potential in limiting cancer spread.

Upstream product

• 4430-39-1 6-(methylthio)hexyl isothiocyanate 

Downstream Products

• 1292802-18-6 C₂₃H₃₆N₄O₅S₂ 

Relevant articles and documents

ω-Methylsulfinylalkyl Isothiocyanates in Wasabi, Wasabia japonica Matsum

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