443116-65-2

Basic information

• Product Name: 2H-Pyrano[2,3-c]pyridine-3-carboxamide, 5-(hydroxymethyl)-2-imino-8-methyl-N-(2-methylphenyl)-
• CAS NO: 443116-65-2
• Molecular Formula: C18H17N3O3
• Molecular Weight: 323.351
• Mol File: 443116-65-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-Pyrano[2,3-c]pyridine-3-carboxamide, 5-(hydroxymethyl)-2-imino-8-methyl-N-(2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyrano[2,3-c]pyridine-3-carboxamide, 5-(hydroxymethyl)-2-imino-8-methyl-N-(2-methylphenyl)-(443116-65-2)
• EPA Substance Registry System: 2H-Pyrano[2,3-c]pyridine-3-carboxamide, 5-(hydroxymethyl)-2-imino-8-methyl-N-(2-methylphenyl)-(443116-65-2)

Safety Data

• Hazardous Substances Data: 443116-65-2(Hazardous Substances Data)

Upstream product

• 59736-34-4 N-(2-methylphenyl)-2-cyanoacetamide 
• 65-22-5 pyridoxal hydrochloride 

Relevant articles and documents

Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides

Several novel 2-imino-5-hydroxymethyl-8-methyl-2H-pyrano[2,3-c]pyridine-3- (N-aryl) carboxamides were prepared by reaction of pyridoxal hydrochloride with various N-arylcyanoacetamides. Reaction of these compounds with aromatic amines furnished a wide series of 2-(N-R-phenyl) imino-5-hydroxymethyl-8-methyl-2H- pyrano[2,3-c]pyridine-3-carboxamides. Antibacterial and antifungal activities of the synthesized compounds were studied. Most of the obtained compounds demonstrated significant activity against bacterial or fungal strains (MIC in the range of 12.5-25 μg/mL), displaying comparable or even better efficacy than the standard drugs.