443305-29-1 Usage
Description
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is a chemical compound with the molecular formula C13H13ClO. It is a derivative of naphthalene and belongs to the class of aldehydes. Its aromatic structure and reactive aldehyde functional group make it a versatile intermediate for the preparation of various chemical compounds.
Uses
Used in Organic Synthesis:
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is used as a building block in organic synthesis for the preparation of various chemical compounds due to its versatile intermediate properties.
Used in Medicinal Chemistry:
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is used as a key intermediate in the development of pharmaceuticals, contributing to the synthesis of potential drug candidates.
Used in Fine Chemicals Production:
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is used as a starting material in the production of fine chemicals, which are essential in various industries such as cosmetics, fragrances, and flavors.
Used in Pharmaceutical Industry:
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is used as a precursor in the synthesis of pharmaceuticals, playing a crucial role in the development of new drugs.
Used in Agrochemicals Production:
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is used as a component in the production of agrochemicals, which are vital for agricultural applications such as pest control and crop protection.
Used in Academic Research and Drug Discovery:
1-CHLORO-5,7-DIMETHYL-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE is used as an important target in academic research and drug discovery efforts, owing to its unique structure and properties.
Check Digit Verification of cas no
The CAS Registry Mumber 443305-29-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,3,3,0 and 5 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 443305-29:
(8*4)+(7*4)+(6*3)+(5*3)+(4*0)+(3*5)+(2*2)+(1*9)=121
121 % 10 = 1
So 443305-29-1 is a valid CAS Registry Number.
443305-29-1Relevant articles and documents
Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor
LaFrate, Andrew L.,Gunther, Jillian R.,Carlson, Kathryn E.,Katzenellenbogen, John A.
experimental part, p. 10075 - 10084 (2009/04/06)
Most patients with hormone-responsive breast cancer eventually develop resistance to traditional antiestrogens such as tamoxifen, and this has become a major obstacle in their treatment. We prepared and characterized the activity of a series of 16 guanylhydrazone small molecules that are designed to block estrogen receptor (ER) activity through a non-traditional mechanism, by directly interfering with coactivator binding to agonist-liganded ER. The inhibitory activity of these compounds was determined in cell-based transcription assays using ER-responsive reporter gene and mammalian two-hybrid assays. Several of the compounds gave IC50 values in the low micromolar range. Two secondary assays were used to confirm that these compounds were acting through the proposed non-traditional mode of estrogen inhibitory action and not as conventional antagonists at the ligand binding site.
A rapid access to coumarin derivatives (using Vilsmeier-Haack and Suzuki cross-coupling reactions)
Hesse, Stéphanie,Kirsch, Gilbert
, p. 1213 - 1215 (2007/10/03)
A four-step preparation of compounds containing a coumarinic moiety is presented. This synthesis involves notably a Suzuki cross-coupling reaction (performed in aqueous media) and a ring closure by formation of δ-lactone.
