443347-10-2

Basic information

• Product Name: (R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DI(3,5-XYLYL)PHOSPHINO)-3,3'-BIPYRIDINE
• Synonyms: (S)-(-)-2,2',6,6'-Tetramethoxy-4,4'-bis(di(3,5-xylyl)phosphino)-3,3'-bipyridine,min.95%CTH-(S)-Xylyl-P-Phos;(r)-(+)-2,2',6,6'-tetramethoxy-4,4'-bis(di(3,5-xylyl)phosphino)-3,3'-bipyridine *cth-(r)-xylyl-p-phos*;(s)-(-)-2,2',6,6'-tetramethoxy-4,4'-bis(di(3,5-xylyl)phosphino)-3,3'-bipyridine *cth-(s)-xylyl-p-phos*;(R)-(+)-2,2'',6,6''-TETRAMETHOXY-4,4''-BIS(DI(3,5-XYLYL)PHOSPHINO)-3,3''-BIPYRIDINE *CTH-(R)-XYLYL-P-PHO;(S)-(-)-2,2',6,6'-Tetramethoxy-4,4'-bis(di(3,5-xylyl)phosphino)-3,3'-bipyridine, CTH-(S)-Xylyl-P-Phos, 95% Application:Asymmetric hydrogenation Store N2Ar;(S)-(-)-2,2',6,6'-Tetramethoxy-4,4'-bis(di(3,5-xylyl)phosphino)-3,3'-bipyridine *CTH-(S)-Xylyl-P-Pho;(3S)-4,4'-Bis[bis(3,5-dimethylphenyl)phosphino]-2,2',6,6'-tetramethoxy-3,3'-bipyridine;(S)-Xyl-P-Phos
• CAS NO: 443347-10-2
• Molecular Formula: C₄₆H₅₀N₂O₄P₂
• Molecular Weight: 756.85
• Mol File: 443347-10-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 158-162°C
• Appearance: white to pale yellow/Powder
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Sparingly soluble in water.
• CAS DataBase Reference: (R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DI(3,5-XYLYL)PHOSPHINO)-3,3'-BIPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DI(3,5-XYLYL)PHOSPHINO)-3,3'-BIPYRIDINE(443347-10-2)
• EPA Substance Registry System: (R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DI(3,5-XYLYL)PHOSPHINO)-3,3'-BIPYRIDINE(443347-10-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36
• WGK Germany: 3
• Hazardous Substances Data: 443347-10-2(Hazardous Substances Data)

Usage

Description

(R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DI(3,5-XYLYL)PHOSPHINO)-3,3'-BIPYRIDINE is a white solid with unique chemical properties that make it suitable for various applications in different industries, particularly in the pharmaceutical sector.

Uses

Used in Pharmaceutical Industry:
(R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DI(3,5-XYLYL)PHOSPHINO)-3,3'-BIPYRIDINE is used as a key compound for the development of new drugs due to its unique chemical structure and properties. Its potential applications in drug discovery and design can lead to the creation of novel therapeutic agents.
Used in Chemical Research:
In the field of chemical research, (R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DI(3,5-XYLYL)PHOSPHINO)-3,3'-BIPYRIDINE serves as a valuable research tool for understanding the interactions between molecules and their biological targets. Its unique structure allows scientists to study its binding properties and potential applications in various chemical and biological processes.
Used in Material Science:
(R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DI(3,5-XYLYL)PHOSPHINO)-3,3'-BIPYRIDINE can be utilized in the development of new materials with specific properties, such as optical, electronic, or catalytic applications. Its unique chemical structure may contribute to the creation of advanced materials with improved performance in various industries.

Reactions

Chiral ligand for the asymmetric hydrogenation of β-keto esters. Chiral ligand for enantioselective rhodium-catalyzed [2+2+2] carbocyclization reactions. Chiral ligand for ruthenium catalyzed hydrogenation of (E)-β-(acylamino)acrylates to β-amino acids. The Rhodium complex gives higher enantioselectivity for hydrogenation of (Z)-β-(acylamino)acrylates to β-amino acids. Chiral ligand for copper-catalyzed asymmetric hydrosilylation of ketones. Chiral ligand for asymmetric allylic substitution reactions using boronic acids as nucleophiles. Gives useful selectivity in asymmetric Pauson-Khand-type cyclizations.

Upstream product

• 442905-31-9 4,4'-bis-[bis-(3,5-dimethyl-phenyl)-phosphinoyl]-2,6,2',6'-tetramethoxy-[3,3']bipyridinyl 
• 13445-16-4 3-bromo-2,6-dimethoxypyridine 
• 34696-73-6 3,5-dimethyphenylmagnesium bromide 
• 74289-57-9 bis-(3,5-dimethylphenyl)chlorophosphine 
• 442686-31-9 4-[bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-bromo-2,6-dimethoxy-pyridine 
• 442686-32-0 4-[bis-(3,5-dimethyl-phenyl)-phosphinoyl]-3-bromo-2,6-dimethoxy-pyridine 

Downstream Products

• 1034001-49-4 [RuCl(p-cymene)((R)-xylyl-P-phos)]Cl 

Relevant articles and documents

A new chiral dipyridylphosphine ligand Xyl-P-Phos and its application in the Ru-catalyzed asymmetric hydrogenation of β-ketoesters

A new chiral dipyridylphosphine ligand Xyl-P-Phos has been synthesized and the structure of (S)-Xyl-P-Phos oxide has been characterized by single crystal X-ray diffraction. The ruthenium complex of this ligand, Ru(R-Xyl-P-Phos)(C6H6)Cl2, has been found to be a highly active, enantioselective and air-stable catalyst for the asymmetric hydrogenation of β-ketoesters and shows good potential for industrial applications.