443347-74-8

Basic information

• Product Name: C₂₂H₁₄ClFN₂O₂S
• Synonyms: C₂₂H₁₄ClFN₂O₂S
• CAS NO: 443347-74-8
• Molecular Weight: 424.883
• Mol File: 443347-74-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₄ClFN₂O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₄ClFN₂O₂S(443347-74-8)
• EPA Substance Registry System: C₂₂H₁₄ClFN₂O₂S(443347-74-8)

Safety Data

• Hazardous Substances Data: 443347-74-8(Hazardous Substances Data)

Upstream product

• 536-38-9 4-chlorobenzoylmethyl bromide 
• 1547-15-5 2-mercapto-3-(4-fluorophenyl)-3H-quinazolin-4-one 
• 118-92-3 anthranilic acid 
• 1544-68-9 4-fluorophenyl isothiocyanate 

Relevant articles and documents

Design, synthesis and anticonvulsant activity of some newer 3H-quinazolin-4-one derivatives

In the present investigation, a series of 2-[2-(aryl)-2-oxo-ethylsulfanyl]- 3-(aryl/propyl)-3H-quinazolin-4-ones have been synthesized and tested for their potential against seizures in mice. All the newly synthesized compounds show moderate to high protection against 6 Hz partial seizure with compound 2b, 2-(2-oxo-2-p-tolyl-ethylsulfanyl)-3-phenyl-3H-quinazolin-4-one emerging as the most active anticonvulsant agent endowed with neuroprotective effect against NMDA and kainate induced excitotoxicity. The results of whole brain GABA assay indicates that the seizure protective activity of 2b can be either due to the increased brain GABA level or due to neuroprotective action.