443770-15-8

Basic information

• Product Name: Propanamide, 3-[(triphenylmethyl)amino]-N-[4-[(triphenylmethyl)amino]butyl]-
• CAS NO: 443770-15-8
• Molecular Formula: C45H45N3O
• Molecular Weight: 643.872
• Mol File: 443770-15-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Propanamide, 3-[(triphenylmethyl)amino]-N-[4-[(triphenylmethyl)amino]butyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 3-[(triphenylmethyl)amino]-N-[4-[(triphenylmethyl)amino]butyl]-(443770-15-8)
• EPA Substance Registry System: Propanamide, 3-[(triphenylmethyl)amino]-N-[4-[(triphenylmethyl)amino]butyl]-(443770-15-8)

Safety Data

• Hazardous Substances Data: 443770-15-8(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 189341-61-5 N₁-Triphenylmethyl-1,4-diaminobutane 
• 58995-27-0 Trt-βAla-OSu 

Downstream Products

• 443770-21-6 15-{[4-(trityl-amino)-butyl]-[3-(trityl-amino)-propyl]-carbamoyl}-pentadecanoic acid 2-oxo-2-phenyl-ethyl ester 
• 443770-22-7 15-{[4-(trityl-amino)-butyl]-[3-(trityl-amino)-propyl]-carbamoyl}-pentadecanoic acid 
• 847830-39-1 trityl-(4-{5-[2-(trityl-amino)-ethyl]-tetrazol-1-yl}-butyl)-amine 
• 244033-13-4 N^α,N^ω-ditritylspermidine 

Relevant articles and documents

Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity

A series of novel hybrids of artemisinin (ART) with either a phytormone endoperoxide G factor analogue (GMeP) or chloroquine (CQ) and conjugates of the same compounds with the polyamines (PAs), spermidine (Spd), and homospermidine (Hsd) were synthesized and their antiplasmodial activity was evaluated using the CQ-resistant P. falciparum FcB1/Colombia strain. The ART-GMeP hybrid 5 and compounds 9 and 10 which are conjugates of Spd and Hsd with two molecules of ART and one molecule of GMeP, were the most potent with IC50 values of 2.6, 8.4, and 10.6 nM, respectively. The same compounds also presented the highest selectivity indexes against the primary human fibroblast cell line AB943 ranging from 16 372 for the hybrid 5 to 983 for the conjugate 10 of Hsd.

Simple syntheses of the polyamine alkaloid tenuilobine and analogues using selectively N-tritylated polyamines and dicarboxylic acids as bridging elements

Selectively N-tritylated spermidine and spermine derivatives and the monophenacyl ester of 1,16-hexadecanedioic acid (Hda) were used to obtain the polyamine alkaloid tenuilobine and its fully reduced analogue. Other symmetric or side-chain-shortened tenui