443955-90-6

Basic information

• Product Name: 2,3-DIHYDRO[1,4]DIOXINO[2,3-C]PYRIDINE-7-CARBALDEHYDE
• Synonyms: 2,3-DIHYDRO[1,4]DIOXINO[2,3-C]PYRIDINE-7-CARBALDEHYDE;2H,3H-[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde;2,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carboxaldehyde;EOS-60313
• CAS NO: 443955-90-6
• Molecular Formula: C8H7NO3
• Molecular Weight: 165.15
• Mol File: 443955-90-6.mol
• Article Data: 19

Chemical Properties

• Melting Point: 120-122 °C
• Boiling Point: 293.012oC at 760 mmHg
• Flash Point: 131.01oC
• Appearance: /
• Density: 1.34g/cm3
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.595
• PKA: 3.98±0.20(Predicted)
• CAS DataBase Reference: 2,3-DIHYDRO[1,4]DIOXINO[2,3-C]PYRIDINE-7-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO[1,4]DIOXINO[2,3-C]PYRIDINE-7-CARBALDEHYDE(443955-90-6)
• EPA Substance Registry System: 2,3-DIHYDRO[1,4]DIOXINO[2,3-C]PYRIDINE-7-CARBALDEHYDE(443955-90-6)

Safety Data

• Hazardous Substances Data: 443955-90-6(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde is a chemical compound with a complex and unique structure. It is a heterocyclic organic compound containing a pyridine ring fused to a dioxine ring, with a carbaldehyde group attached to the 7th carbon. 2,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde has potential applications in the pharmaceutical and agrochemical industries due to its diverse structural features, which offer opportunities for the development of novel drugs and pesticides. Its specific properties and potential uses make it a subject of interest for researchers and chemists in various fields of study.

InChI:InChI=1/C8H7NO3/c10-5-6-3-7-8(4-9-6)12-2-1-11-7/h3-5H,1-2H2

Upstream product

• 443955-89-3 (2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-methanol 
• 501-30-4 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 
• 15771-06-9 5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one 
• 59281-14-0 5-benzyloxy-2-hydroxymethyl-1H-pyridin-4-one 
• 31883-16-6 6-hydroxymethyl-3-hydroxy-4-pyridinone 

Downstream Products

• 443955-89-3 (2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-methanol 
• 527681-13-6 2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxylic acid 
• 1065677-78-2 Phenylmethyl (3R,4S)-4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-3-hydroxy-1-piperidinecarboxylate 
• 1065678-06-9 1-(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-yl)-N-{[4-(phenylmethyl)-2-morpholinyl]methyl}methanamine 
• 1421236-81-8 (R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-1-(2,3-dihydro-[1,4]-dioxino[2,3-c]pyridin-7-yl)-2-methyl-3-oxopropyl)-2-methylpropane-2-sulfinamide 
• 1075258-45-5 (6R)-6-({4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de]-1,5-naphthyridin-8-one benzoate 

Relevant articles and documents

Development of the Convergent, Kilogram-Scale Synthesis of an Antibacterial Clinical Candidate Using Enantioselective Hydrogenation

Early chemical development studies into the best way of assembling AZD9742, an antibacterial drug candidate, have involved swapping the order of two reductive aminations. The orthogonally functionalized aminopiperidine partner for these couplings is now enantioselectively synthesized using ruthenium-catalyzed asymmetric hydrogenation. The challenge of controlling defluorination through an appropriate catalyst choice has hitherto prevented this revised sequence from reaching its full potential. However, it is still shown to allow access to the active pharmaceutical ingredient in a stereochemically pure form and has been demonstrated on a multikilogram scale. The reductive aminations in both the original and revised sequences provided different scale-up challenges, and the solutions implemented are described.

CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER

[Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)

NOVEL NAPHTHYRIDINE DERIVATIVE MONOHYDRATE AND METHOD FOR PRODUCING THE SAME

Disclosed is 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one monohydrate, which has strong antibacterial activity. The compound is highly safe and useful as an original drug for ph