443956-11-4

Basic information

• Product Name: 3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehyde
• Synonyms: 3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehyde
• CAS NO: 443956-11-4
• Molecular Formula: C₈H₆N₂O₃
• Molecular Weight: 178.14484
• Mol File: 443956-11-4.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehyde(443956-11-4)
• EPA Substance Registry System: 3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehyde(443956-11-4)

Safety Data

• Hazardous Substances Data: 443956-11-4(Hazardous Substances Data)

Usage

General Description

3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehyde is a chemical compound with the molecular formula C9H7NO3. It is also known as isoniazid, an anti-tuberculosis medication. It is a hydrazide and a carboxamide that is chemically related to nicotinamide and pyridoxine. Isoniazid functions as a prodrug, meaning it is not active in its current form but is instead transformed by bacteria into isonicotinic acid, which is the active component in the treatment of tuberculosis. It works by inhibiting the synthesis of mycolic acid, an essential component of the bacterial cell wall, thereby disrupting the growth and multiplication of tuberculosis bacteria. Isoniazid is a crucial component of the standard treatment regimen for both latent and active tuberculosis infections.

Upstream product

• 443956-10-3 (E)-6-styryl-2H-pyrido-[3,2-b][1,4]-oxazin-3(4H)-one 
• 615568-38-2 6-(hydroxymethyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 
• 911485-89-7 C₁₅H₁₂N₂O₂ 
• 443956-08-9 6-bromo-2-nitropyridin-3-ol 
• 443956-09-0 ethyl 2-(6-bromo-2-nitropyridin-3-yloxy)acetate 
• 337463-88-4 6-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 
• 201230-82-2 carbon monoxide 
• 15128-82-2 3-hydroxy-2-nitropyridine 

Downstream Products

• 615568-38-2 6-(hydroxymethyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 

Relevant articles and documents

BRIDGED COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS

Novel bridged compounds are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antibacterial agents. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating bacterial infections and associated diseases and conditions.

BRIDGED BICYCLIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS

Novel bridged bicyclic compounds are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antibacterial agents. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating bacterial infections and associated diseases and conditions.

The design of efficient and selective routes to pyridyl analogues of 3-oxo-3,4-dihydro-2H-1,4-(benzothiazine or benzoxazine)-6-carbaldehydes

This Letter describes the synthesis of challenging pyridyl analogues of 3-oxo-3,4-dihydro-2H-1,4-(benzothiazine or benzoxazine)-6-carbaldehydes. The six different routes described are high yielding, contain no major purification issues and have been used to give gram quantities of each aldehyde.